Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationFront Psychiatry. 2014, 5:1-17
AbstractSeveral studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single gene disorders associated with an increased risk for autism. Furthermore, several studies suggest a role of environmental factors in autism spectrum disorders (ASD). First, arguments for a genetic contribution to autism, based on updated family and twin studies, are examined. Second, a review of possible prenatal, perinatal, and postnatal environmental risk factors for ASD are presented. Then, the hypotheses are discussed concerning the underlying mechanisms related to a role of environmental factors in the development of ASD in association with genetic factors. In particular, epigenetics as a candidate biological mechanism for gene × environment interactions is considered and the possible role of epigenetic mechanisms reported in genetic disorders associated with ASD is discussed. Furthermore, the example of in utero exposure to valproate provides a good illustration of epigenetic mechanisms involved in ASD and innovative therapeutic strategies. Epigenetic remodeling by environmental factors opens new perspectives for a better understanding, prevention, and early therapeutic intervention of ASD.
DescriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.
- [Epigenetics' implication in autism spectrum disorders: A review].
- Authors: Hamza M, Halayem S, Mrad R, Bourgou S, Charfi F, Belhadj A
- Issue date: 2017 Aug
- [Genetic, environmental, and epigenetic contribution to the susceptibility to autism spectrum disorders].
- Authors: Díaz-Anzaldúa A, Díaz-Martínez A
- Issue date: 2013 Dec 16
- DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?
- Authors: Keil KP, Lein PJ
- Issue date: 2016 Mar
- Epigenetics of Autism Spectrum Disorder.
- Authors: Siu MT, Weksberg R
- Issue date: 2017
- The Interaction between the Immune System and Epigenetics in the Etiology of Autism Spectrum Disorders.
- Authors: Nardone S, Elliott E
- Issue date: 2016