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The alcohol paradox: light-to-moderate alcohol consumption, cognitive function, and brain volume.

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Authors
Davis, Benjamin J K
Vidal, Jean-Sebastian
Garcia, Melissa
Aspelund, Thor
van Buchem, Mark A
Jonsdottir, Maria K
Sigurdsson, Sigurdur
Harris, Tamara B
Gudnason, Vilmundur
Launer, Lenore J
Issue Date
2014-12

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Citation
J. Gerontol. A Biol. Sci. Med. Sci. 2014, 69 (12):1528-35
Abstract
Studies of older persons show consumption of light-to-moderate amounts of alcohol is positively associated with cognitive function and, separately, is negatively associated with total brain volume (TBV). This is paradoxical as generally, cognitive function is positively associated with TBV. We examined the relationships of TBV, global cognitive function (GCF), and alcohol consumption in a population-based cohort of 3,363 men and women (b. 1907-1935) participating in the Age Gene/Environment Susceptibility-Reykjavik Study (2002-2006) and who were free of dementia or mild cognitive impairment
Drinking status (never, former, and current) and current amount of alcohol consumed were assessed by questionnaire. GCF is a composite score derived from a battery of cognitive tests. TBV, standardized to head size, is estimated quantitatively from brain magnetic resonance imaging.
Among women and not men, adjusting for demographic and cardiovascular risk factors, current drinkers had significantly higher GCF scores than abstainers and former drinkers (p < .0001); and GCF was associated with amount consumed. TBV was not associated with drinking status or amount consumed in men or women. GCF and TBV did significantly differ in their associations across alcohol categories (p interaction < .001). Within categories of alcohol intake, GCF and TBV were positively associated.
The difference in associations of alcohol intake to brain structure and function suggests there may be unmeasured factors that contribute to maintaining better GCF relative to TBV. However, at higher levels of reasonable alcohol consumption, there may be factors leading to reduced brain volume.
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To access publisher's full text version of this article click on the hyperlink at the bottom of the page
Additional Links
http://dx.doi.org/10.1093/gerona/glu092
http://biomedgerontology.oxfordjournals.org/content/69/12/1528.full.pdf
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Archived with thanks to The journals of gerontology. Series A, Biological sciences and medical sciences
ae974a485f413a2113503eed53cd6c53
10.1093/gerona/glu092
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