Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationEur J Clin Nutr 2004, 58(5):812-8
AbstractOBJECTIVE: The aim of the study was to assess the relationship between size at birth and obesity as well as truncal fat, and its contribution to cardiovascular risk in a high birth weight population. DESIGN: Cohort-study with retrospectively collected data on size at birth. SETTING: Reykjavik, Iceland. SUBJECTS: A total of 1874 men and 1833 women born in Reykjavik during 1914-1935. MAIN OUTCOME MEASURES: Size at birth. Adult weight, height and skinfold thickness measurements, systolic and diastolic blood pressure, fatal and nonfatal coronary heart disease (CHD). RESULTS: Birth weight was positively related to adult body mass index (BMI) in both genders (B=0.35+/-0.14 kg/m(2), adj. R(2)=0.015, P=0.012 and B=0.34+/-0.17 kg/m(2), adj. R(2)=0.055, P=0.043 in men and women, respectively). However, high birth weight was not a risk factor for adult obesity (BMI>/=30 kg/m(2)). In the highest birth weight quartile, the odds ratio (95% CI) for being above the 90th percentile of truncal fat was 0.7 (0.6-1.0, P=0.021) for men and 0.4 (0.3-0.8, P=0.002) for women, compared with the lowest birth weight quartile. Truncal fat and BMI were positively related to blood pressure in both genders (P<0.05), but not to CHD. The regression coefficient for the inverse association between birth weight and blood pressure hardly changed when adding truncal fat to the model. CONCLUSION: In this high birth weight population, high birth weight was related to higher BMI in adulthood without being a risk factor for adult obesity. The inverse association between birth weight and truncal fat in adulthood suggests a role for foetal development in determining adult fat distribution. The inverse relationship of birth weight to blood pressure seems not to be mediated through the same pathway as to truncal fat.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Birth weight, adult body composition, and subcutaneous fat distribution.
- Authors: Te Velde SJ, Twisk JW, Van Mechelen W, Kemper HC
- Issue date: 2003 Feb
- Contribution of body fat and fat pattern to blood pressure level in school children.
- Authors: Moussa MA, Skaik MB, Selwanes SB, Yaghy OY, Bin-Othman SA
- Issue date: 1994 Aug
- [Body fat distribution: its characteristics and relationship to cardiovascular risk factors in obese Chinese].
- Authors: Ran XW, Li XS, Tong NW, Li QF, Tang BD, Li XJ
- Issue date: 2004 Sep
- Birth size, adult body composition and muscle strength in later life.
- Authors: Ylihärsilä H, Kajantie E, Osmond C, Forsén T, Barker DJ, Eriksson JG
- Issue date: 2007 Sep
- The influence of obesity and consequent insulin resistance on coronary risk factors in medically treated patients with coronary disease.
- Authors: Ades PA, Savage PD, Toth MJ, Schneider DJ, Audelin MC, Bunn JY, Ludlow M
- Issue date: 2008 Jun