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dc.contributor.authorJohnston, A
dc.contributor.authorArnadottir, S
dc.contributor.authorGudjonsson, J E
dc.contributor.authorAphale, A
dc.contributor.authorSigmarsdottir, A A
dc.contributor.authorGunnarsson, S I
dc.contributor.authorSteinsson, J T
dc.contributor.authorElder, J T
dc.contributor.authorValdimarsson, H
dc.date.accessioned2008-08-13T10:48:05Z
dc.date.available2008-08-13T10:48:05Z
dc.date.issued2008-06-11
dc.date.submitted2008-08-13
dc.identifier.citationBr. J. Dermatol. 2008, 159(2):342-350en
dc.identifier.issn0007-0963
dc.identifier.pmid18547319
dc.identifier.doi10.1111/j.1365-2133.2008.08655.x
dc.identifier.urihttp://hdl.handle.net/2336/35292
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBackground Obesity is a significant risk factor for psoriasis and body mass index (BMI) correlates with disease severity. Objectives To investigate the relationship between obesity and psoriasis, focusing on the role of adipokines such as leptin and resistin. Patients/methods Patients with psoriasis (n = 30) were recruited and their BMI, waist circumference and disease severity [Psoriasis Area and Severity Index (PASI)] were recorded. Fasting serum samples were obtained on enrolment and after a course of ultraviolet (UV) B treatment. Age-, sex- and BMI-matched healthy controls were also recruited. Results On enrolment, serum leptin and soluble leptin receptor levels were not raised compared with the controls. However, resistin, interleukin (IL)-1beta, IL-6, and chemokines CCL2, CXCL8 and CXCL9 were all significantly elevated in the patient group and serum resistin correlated with disease severity (r = 0.372, P = 0.043). Improvement after UVB treatment was accompanied by decreased serum CXCL8. In vitro, both leptin and resistin could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes, and leptin could additionally induce IL-1beta and IL-1 receptor antagonist production. Leptin also dose dependently increased secretion of the growth factor amphiregulin by ex vivo-cultured lesional psoriasis skin. Conclusions These data support the view that leptin and resistin may be involved in the pathogenesis of psoriasis in overweight individuals, possibly by augmenting the cytokine expression by the inflammatory infiltrate.
dc.languageENG
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://dx.doi.org/10.1111/j.1365-2133.2008.08655.xen
dc.subject.meshPsoriasisen
dc.subject.meshObesityen
dc.subject.meshLeptinen
dc.subject.meshCytokinesen
dc.titleObesity in psoriasis: leptin and resistin as mediators of cutaneous inflammationn/a
dc.typeArticleen
dc.identifier.eissn1365-2133
dc.contributor.departmentDepartment of Immunology, Landspitali University Hospital, Reykjavik, Iceland.en
dc.identifier.journalBritish journal of dermatologyen
html.description.abstractBackground Obesity is a significant risk factor for psoriasis and body mass index (BMI) correlates with disease severity. Objectives To investigate the relationship between obesity and psoriasis, focusing on the role of adipokines such as leptin and resistin. Patients/methods Patients with psoriasis (n = 30) were recruited and their BMI, waist circumference and disease severity [Psoriasis Area and Severity Index (PASI)] were recorded. Fasting serum samples were obtained on enrolment and after a course of ultraviolet (UV) B treatment. Age-, sex- and BMI-matched healthy controls were also recruited. Results On enrolment, serum leptin and soluble leptin receptor levels were not raised compared with the controls. However, resistin, interleukin (IL)-1beta, IL-6, and chemokines CCL2, CXCL8 and CXCL9 were all significantly elevated in the patient group and serum resistin correlated with disease severity (r = 0.372, P = 0.043). Improvement after UVB treatment was accompanied by decreased serum CXCL8. In vitro, both leptin and resistin could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes, and leptin could additionally induce IL-1beta and IL-1 receptor antagonist production. Leptin also dose dependently increased secretion of the growth factor amphiregulin by ex vivo-cultured lesional psoriasis skin. Conclusions These data support the view that leptin and resistin may be involved in the pathogenesis of psoriasis in overweight individuals, possibly by augmenting the cytokine expression by the inflammatory infiltrate.


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