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Creutzfeldt-Jakob sjúkdómur og riða í sauðfé

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Authors
Guðmundur Georgsson
Elías Ólafsson
Gunnar Guðmundsson
Issue Date
2008-08-15

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Other Titles
Scrapie of sheep and Creutzfeldt-Jakob disease in Iceland
Citation
Læknablaðið 2008, 94(7):541-48
Abstract
Objective: Scrapie of sheep and Creutzfeldt-Jakob disease (CJD) are both classified as prion diseases. The infectious agents of both diseases are closely related. The objectives of the study was to explore, whether sheep scrapie could be transmitted to humans and cause CJD. Material and methods: The occurrence of CJD was studied in a period of 40 years, 1960 to 2000. The first part of the study, which was started in 1980, was retrospective. Hospital records from the Department of Neurology of the National Hospital from the years 1960-1980 were scrutinised and paraffin blocks from the collection of the Department of Pathology from cases with the diagnosis CJD and some suspect cases were obtained and analysed. The latter part of the study was prospective, which gave the possibility to study codon 129 of PRNP gene and characterise the strain of the infectious agent. Information on the epidemiology of scrapie in Iceland and of the diet of Icelanders was collected. Results: Four cases of CJD were detected in the 40 years studied, which corresponds to an incidence of 0.44 per million inhabitants, which is less than half the average incidence in 18 other European countries in the years 1997-2004. Conclusion: The low incidence of CJD in Iceland does not indicate that sheep scrapie can be transmitted to humans and cause CJD. If this were the case, we would have excpected an higher incidence of CJD and possibly atypical cases, as the Icelandic population has been exposed to scrapie for 130 years. Keywords: prions, sheep scrapie, Creutzfeldt-Jakob disease, epidemiology. Correspondence: Gudmundur Georgsson, ggeorgs@hi.is.
Tilgangur: Sauðfjárriða og Creutzfeldt-Jakob sjúkdómur (CJD) hjá mönnum teljast til príonsjúkdóma og smitefni þeirra eru náskyld. Leitað var svara við spurningunni hvort sauðfjárriða gæti borist í menn og valdið CJD. Efniviður og aðferðir: Skimað var fyrir CJD á 40 ára tímabili, 1960-2000. Afturskyggn rannsókn hófst 1980. Sjúkraskrár taugasjúkdómadeildar Landspítalans frá árunum 1960-1980 voru kannaðar. Rannsakaðir voru vefjabitar (vaxkubbar) úr safni rannsóknar­stofu HÍ við Barónsstíg af tilfellum, sem höfðu verið greind sem CJD eða rökstuddur grunur var um þá greiningu.Við framskyggnu rannsóknina 1980-2000 gafst einnig færi á að kanna tákna 129 í erfðaefni príons og auðkenna stofn smitefnis. Teknar voru saman upplýsingar um faraldsfræði riðu og neysluvenjur landans kannaðar. Niðurstöður: 4 tilfelli af CJD voru greind á þessum 40 árum, tvö á hvoru tímabili. Árleg dánartíðni var 0,44 á milljón íbúa. Ályktun: Þar eð tíðnin hérlendis er ríflega helmingi lægri en meðaltalstíðni í 18 öðrum Evrópulöndum á tímabilinu 1997-2004, sem var 1,11 á milljón íbúa, teljum við næsta víst að sauðfjárriða berist ekki í fólk, enda hefði má búast við hærri tíðni CJD hérlendis og hugsanlega afbrigðilegum tilfellum ef svo væri því Íslendingar hafa verið útsettir fyrir riðu í 130 ár.
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