Evidence against PALB2 involvement in Icelandic breast cancer susceptibility
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Gunnarsson, HaukurArason, Adalgeir
Gillanders, Elizabeth M
Agnarsson, Bjarni A
Johannesdottir, Gudrun
Johannsson, Oskar Th
Barkardottir, Rosa B
Issue Date
2008-07-17
Metadata
Show full item recordCitation
J Negat Results Biomed. 2008, 7:5Abstract
ABSTRACT: Several mutations in the PALB2 gene (partner and localizer of BRCA2) have been associated with an increased risk of breast cancer, including a founder mutation, 1592delT, reported in Finnish breast cancer families. Although most often the risk is moderate, it doesn't exclude families with high-risk mutations to exist and such observations have been reported. To see if high-risk PALB2-mutations may be present in the geographically confined population of Iceland, linkage analysis was done on 111 individuals, thereof 61 breast cancer cases, from 9 high-risk non-BRCA1/BRCA2 breast cancer families, targeting the PALB2 region. Also, screening for the 1592delT founder mutation in the 9 high-risk families and in 638 unselected breast cancer cases was performed. The results indicate no linkage in any of the high-risk families and screening for the 1592delT mutation was negative in all samples. PALB2 appears not to be a significant factor in high-risk breast cancer families in Iceland and the 1592delT mutation is not seen to be associated with breast cancer in Iceland.Description
To access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this pageAdditional Links
http://www.jnrbm.com/content/7/1/5ae974a485f413a2113503eed53cd6c53
10.1186/1477-5751-7-5
Scopus Count
Collections
Related articles
- Penetrance analysis of the PALB2 c.1592delT founder mutation.
- Authors: Erkko H, Dowty JG, Nikkilä J, Syrjäkoski K, Mannermaa A, Pylkäs K, Southey MC, Holli K, Kallioniemi A, Jukkola-Vuorinen A, Kataja V, Kosma VM, Xia B, Livingston DM, Winqvist R, Hopper JL
- Issue date: 2008 Jul 15
- The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype.
- Authors: Heikkinen T, Kärkkäinen H, Aaltonen K, Milne RL, Heikkilä P, Aittomäki K, Blomqvist C, Nevanlinna H
- Issue date: 2009 May 1
- A recurrent mutation in PALB2 in Finnish cancer families.
- Authors: Erkko H, Xia B, Nikkilä J, Schleutker J, Syrjäkoski K, Mannermaa A, Kallioniemi A, Pylkäs K, Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Kataja V, Soini Y, Drapkin RI, Livingston DM, Winqvist R
- Issue date: 2007 Mar 15
- Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families.
- Authors: García MJ, Fernández V, Osorio A, Barroso A, Llort G, Lázaro C, Blanco I, Caldés T, de la Hoya M, Ramón Y Cajal T, Alonso C, Tejada MI, San Román C, Robles-Díaz L, Urioste M, Benítez J
- Issue date: 2009 Feb
- PALB2 mutations 1592delT and 229delT are not present in Korean breast cancer patients negative for BRCA1 and BRCA2 mutations.
- Authors: Kim JH, Choi DH, Cho DY, Ahn SH, Son BH, Haffty BG
- Issue date: 2010 Jul