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Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

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Authors
Kiemeney, Lambertus A
Thorlacius, Steinunn
Sulem, Patrick
Geller, Frank
Aben, Katja K H
Stacey, Simon N
Gudmundsson, Julius
Jakobsdottir, Margret
Bergthorsson, Jon T
Sigurdsson, Asgeir
Blondal, Thorarinn
Witjes, J Alfred
Vermeulen, Sita H
Hulsbergen-van de Kaa, Christina A
Swinkels, Dorine W
Ploeg, Martine
Cornel, Erik B
Vergunst, Henk
Thorgeirsson, Thorgeir E
Gudbjartsson, Daniel
Gudjonsson, Sigurjon A
Thorleifsson, Gudmar
Kristinsson, Kari T
Mouy, Magali
Snorradottir, Steinunn
Placidi, Donatella
Campagna, Marcello
Arici, Cecilia
Koppova, Kvetoslava
Gurzau, Eugene
Rudnai, Peter
Kellen, Eliane
Polidoro, Silvia
Guarrera, Simonetta
Sacerdote, Carlotta
Sanchez, Manuel
Saez, Berta
Valdivia, Gabriel
Ryk, Charlotta
de Verdier, Petra
Lindblom, Annika
Golka, Klaus
Bishop, D Timothy
Knowles, Margaret A
Nikulasson, Sigfus
Petursdottir, Vigdis
Jonsson, Eirikur
Geirsson, Gudmundur
Kristjansson, Baldvin
Mayordomo, Jose I
Steineck, Gunnar
Porru, Stefano
Buntinx, Frank
Zeegers, Maurice P
Fletcher, Tony
Kumar, Rajiv
Matullo, Giuseppe
Vineis, Paolo
Kiltie, Anne E
Gulcher, Jeffrey R
Thorsteinsdottir, Unnur
Kong, Augustine
Rafnar, Thorunn
Stefansson, Kari
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Issue Date
2008-11-01

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Citation
Nat. Genet. 2008, 40(11):1307-12
Abstract
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).
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http://dx.doi.org/10.1038/ng.229
ae974a485f413a2113503eed53cd6c53
10.1038/ng.229
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English Journal Articles (Peer Reviewed)

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