Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
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AuthorsKiemeney, Lambertus A
Aben, Katja K H
Stacey, Simon N
Bergthorsson, Jon T
Witjes, J Alfred
Vermeulen, Sita H
Hulsbergen-van de Kaa, Christina A
Swinkels, Dorine W
Cornel, Erik B
Thorgeirsson, Thorgeir E
Gudjonsson, Sigurjon A
Kristinsson, Kari T
de Verdier, Petra
Bishop, D Timothy
Knowles, Margaret A
Mayordomo, Jose I
Zeegers, Maurice P
Kiltie, Anne E
Gulcher, Jeffrey R
MetadataShow full item record
CitationNat. Genet. 2008, 40(11):1307-12
AbstractWe conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).
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- Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study.
- Authors: Cortessis VK, Yuan JM, Van Den Berg D, Jiang X, Gago-Dominguez M, Stern MC, Castelao JE, Xiang YB, Gao YT, Pike MC, Conti DV
- Issue date: 2010 Dec
- Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population.
- Authors: Wang M, Wang M, Zhang W, Yuan L, Fu G, Wei Q, Zhang Z
- Issue date: 2009 Jun
- Genetic polymorphisms on 8q24.1 and 4p16.3 are not linked with urothelial carcinoma of the bladder in contrast to their association with aggressive upper urinary tract tumours.
- Authors: Yates DR, Rouprêt M, Drouin SJ, Audouin M, Cancel-Tassin G, Comperat E, Bitker MO, Cussenot O
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- Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.
- Authors: Stern MC, Van Den Berg D, Yuan JM, Conti DV, Gago-Dominguez M, Pike MC, Xiang YB, Gao YT, Cortessis VK
- Issue date: 2009 Nov
- A functional variant in TP63 at 3q28 associated with bladder cancer risk by creating an miR-140-5p binding site.
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- Issue date: 2016 Jul 1