Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Arnar, David O
Valdimarsson, Einar Mar
Gulcher, Jeffrey Robert
Ringelstein, E Bernd
Gudbjartsson, Daniel Fannar
MetadataShow full item record
CitationAnn. Neurol. 2008, 64(4):402-9
AbstractOBJECTIVE: To find sequence variants that associate with the risk for ischemic stroke (IS), we performed a genome-wide association study. METHODS: We genotyped 1,661 Icelandic IS patients and 10,815 control subjects using the Infinium HumanHap300 chip (Illumina, San Diego, CA). A total of 310,881 single nucleotide polymorphisms (SNPs) were tested for association with IS, and the most significant signals were replicated in two large European IS sample sets (2,224 cases/2,583 control subjects). Two SNPs, rs2200733 and rs10033464, were tested further in additional European IS samples (2,327 patients and 16,760 control subjects). RESULTS: In the Icelandic samples and the two replication sets combined, rs2200733 associated significantly with cardioembolic stroke (CES) (odds ratio [OR], 1.54; p = 8.05 x 10(-9)). No other variants associated with IS or any of its subtypes. rs2200733 associated significantly with IS in all sample sets combined (OR, 1.26; p = 2.18 x 10(-10)), and both rs2200733 and its neighbour, rs10033464 associated strongly with CES (rs2200733: OR, 1.52; p = 5.8 x 10(-12); rs10033464: OR, 1.27; p = 6.1 x 10(-4)). Interestingly, rs2200733 also showed significant association to IS not classified as CES. INTERPRETATION: We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES. The association with noncardiogenic stroke is intriguing and suggests that atrial fibrillation may be underdiagnosed in patients presenting with stroke. This discovery may have implications for workup and treatment of IS.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.
- Authors: Husser D, Adams V, Piorkowski C, Hindricks G, Bollmann A
- Issue date: 2010 Feb 23
- Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.
- Authors: Lee KT, Yeh HY, Tung CP, Chu CS, Cheng KH, Tsai WC, Lu YH, Chang JG, Sheu SH, Lai WT
- Issue date: 2010
- The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients.
- Authors: Wnuk M, Pera J, Jagiełła J, Szczygieł E, Ferens A, Spisak K, Wołkow P, Kmieć M, Burkot J, Chrzanowska-Waśko J, Turaj W, Słowik A
- Issue date: 2011 Mar-Apr
- Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis.
- Authors: Cao YY, Ma F, Wang Y, Wang DW, Ding H
- Issue date: 2013 Oct
- Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients.
- Authors: Henningsen KM, Olesen MS, Haunsoe S, Svendsen JH
- Issue date: 2011 Dec