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Subclinical intestinal inflammation: an inherited abnormality in Crohn's disease relatives?

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Authors
Thjodleifsson, Bjarni
Sigthorsson, Gudmundur
Cariglia, Nick
Reynisdottir, Inga
Gudbjartsson, Daniel F
Kristjansson, Kristleifur
Meddings, Jonathan B
Gudnason, Vilmundur
Wandall, Johan H
Andersen, Leif Percival
Sherwood, Roy
Kjeld, Matthias
Oddsson, Einar
Gudjonsson, Hallgrimur
Bjarnason, Ingvar
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Issue Date
2003-06-01

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Gastroenterology 2003, 124(7):1728-37
Abstract
BACKGROUND & AIMS: One approach to unraveling the genetics of complex inherited disease, such as Crohn's disease, is to search for subclinical disease markers among unaffected family members. We assessed the possible presence, prevalence, and inheritance pattern of subclinical intestinal inflammation in apparently healthy relatives of patients with Crohn's disease. METHODS: A total of 49 patients with Crohn's disease, 16 spouses, and 151 (58%) of 260 available first-degree relatives underwent a test for intestinal inflammation (fecal calprotectin concentration). The mode of inheritance was assessed from 36 index patients (by variance component analysis) when more than 50% of relatives were studied. RESULTS: Fecal calprotectin concentrations in patients with Crohn's disease (47 mg/L; confidence interval [CI], 27-95 mg/L) and relatives (11 mg/L; CI, 9-14 mg/L) differed significantly (P < 0.0001) from controls (4 mg/L; CI, 3-5 mg/L), whereas that of the spouses did not (4 mg/L; CI, 3-6 mg/L; P > 0.5). Fecal calprotectin concentration was increased in 49% of all relatives studied. The increased fecal calprotectin concentration among the relatives of the 36 index patients had an inheritance pattern that was most consistent with an additive inheritance pattern. CONCLUSIONS: There is a high prevalence of subclinical intestinal inflammation in first-degree relatives of patients with Crohn's disease that conforms best to an additive inheritance pattern. The genetic basis for this abnormality may represent a risk factor for Crohn's disease.
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http://www.sciencedirect.com/science/article/B6WFX-48TKRJT-H/2/d9547216e29f3b641e1d9a59b18a4bdc
ae974a485f413a2113503eed53cd6c53
doi:10.1016/S0016-5085(03)00383-4
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English Journal Articles (Peer Reviewed)

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