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dc.contributor.authorJonsdottir, Kristin
dc.contributor.authorKristjansson, Mar
dc.contributor.authorHjaltalin Olafsson, Jon
dc.contributor.authorSteingrimsson, Olafur
dc.date.accessioned2006-09-22T11:15:35Z
dc.date.available2006-09-22T11:15:35Z
dc.date.issued2003-03-01
dc.identifier.citationSex Transm Dis 2003, 30(3):249-56en
dc.identifier.issn0148-5717
dc.identifier.pmid12616146
dc.identifier.otherTMD12
dc.identifier.otherDAV12
dc.identifier.urihttp://hdl.handle.net/2336/4555
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: The diversity in MOMP (major outer membrane protein) of Chlamydia trachomatis is thought to be necessary for the bacteria to survive in its environment. The rate of change in the omp1 gene (coding for MOMP) is not known. Iceland offers a good opportunity to study the epidemiology of chlamydial infections because the population is small (280,000) and geographically well defined. GOAL: The goal was to determine the number and distribution of genotypes in a population attending the STD clinic in Reykjavík and to assess changes in omp1 sequences over a period of 2 years. STUDY DESIGN: Three-hundred thirty isolates of C trachomatis collected periodically from January 1999 to January 2001 were omp1 genotyped with nested PCR and sequencing. RESULTS: The serotypes found, in descending order of prevalence, were E, D, J, F, K, G, H, and I. Eighteen distinctive genotypes were found. During the study period no significant changes in frequency of genotypes were noted, and introduction of new or changed genotypes was not observed. CONCLUSION: The results indicate a relatively stable situation of genotypes and suggest an ecological advantage of serotype E.
dc.language.isoenen
dc.publisherJ B Lippincotten
dc.relation.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00007435-200303000-00015&LSLINK=80&D=ovften
dc.subject.meshChlamydia Infectionsen
dc.subject.meshChlamydia trachomatisen
dc.subject.meshDNA Primersen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshIceland/epidemiologyen
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshPorinsen
dc.subject.meshPrevalenceen
dc.subject.meshResearch Support, Non-U.S. Gov'ten
dc.subject.meshSeasonsen
dc.subject.meshSerotypingen
dc.titleThe molecular epidemiology of genital Chlamydia trachomatis in the greater Reykjavik area, Icelanden
dc.typeArticleen
dc.identifier.journalSexually transmitted diseasesen
dc.format.digYES
html.description.abstractBACKGROUND: The diversity in MOMP (major outer membrane protein) of Chlamydia trachomatis is thought to be necessary for the bacteria to survive in its environment. The rate of change in the omp1 gene (coding for MOMP) is not known. Iceland offers a good opportunity to study the epidemiology of chlamydial infections because the population is small (280,000) and geographically well defined. GOAL: The goal was to determine the number and distribution of genotypes in a population attending the STD clinic in Reykjavík and to assess changes in omp1 sequences over a period of 2 years. STUDY DESIGN: Three-hundred thirty isolates of C trachomatis collected periodically from January 1999 to January 2001 were omp1 genotyped with nested PCR and sequencing. RESULTS: The serotypes found, in descending order of prevalence, were E, D, J, F, K, G, H, and I. Eighteen distinctive genotypes were found. During the study period no significant changes in frequency of genotypes were noted, and introduction of new or changed genotypes was not observed. CONCLUSION: The results indicate a relatively stable situation of genotypes and suggest an ecological advantage of serotype E.


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