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N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: a randomized controlled trial

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Authors
Ahola, Terhi
Lapatto, Risto
Raivio, Kari O
Selander, Bo
Stigson, Lennart
Jonsson, Baldvin
Jonsbo, Finn
Esberg, Gitte
Stövring, Sören
Kjartansson, Sveinn
Stiris, Tom
Lossius, Kristin
Virkola, Kristina
Fellman, Vineta
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Issue Date
2003-12-01

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Citation
J. Pediatr. 2003, 143(6):713-9
Abstract
OBJECTIVE: To evaluate whether N-acetylcysteine (NAC) infusion during the first week of life reduces the risk of death or bronchopulmonary dysplasia (BPD) in infants with extremely low birth weight.Study design In a Nordic multicenter, double-blind trial, infants (n=391) weighing 500 to 999 g and on ventilator or nasal continuous positive airway pressure were randomized before the age of 36 hours to receive NAC 16 to 32 mg/kg/d (n=194) or placebo (n=197) intravenously for 6 days. Primary end points were death or BPD, defined as supplementary oxygen requirement at 36 weeks' gestational age. RESULTS: There was no difference in the combined incidence of the primary end points death or BPD, 51% vs. 49%, between the NAC group and control group. Also similar was the incidence of BPD in survivors at 36 weeks' gestational age, 40% vs. 40%, and the mean oxygen requirement at the age of 28 days, 31.2% vs. 30.7%, respectively. The severity of BPD was similar in both groups. CONCLUSIONS: A 6-day course of intravenous N-acetylcysteine at the dosage used does not prevent BPD or death in infants with extremely low birth weight.
Additional Links
http://dx.doi.org/10.1067/S0022-3476(03)00419-0
ae974a485f413a2113503eed53cd6c53
doi:10.1067/S0022-3476(03)00419-0
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English Journal Articles (Peer Reviewed)

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