Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?
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CitationClin. Exp. Immunol. 1999, 117(3):580-6
AbstractPsoriasis is a T cell-mediated inflammatory skin disease that has been associated with infections by group A beta-haemolytic streptococci. In a previous study of patients with active psoriasis we demonstrated an increased frequency of circulating Th1-like cells that responded to 20 amino acid (aa) streptococcal M-peptides sharing sequences with human keratin. These cells disappeared after ultraviolet B (UVB)-induced clinical remission. Using T cells from the blood of 17 psoriatic patients and 17 healthy controls we have now compared the numbers of interferon-gamma (IFN-gamma)-producing cells induced by seven 18-20 aa keratin peptides and five corresponding M-peptides. The most frequent and strongest responses were observed to a peptide from keratin 17 that shares ALEEAN sequence with M-protein. The responses to this peptide were stronger than to the corresponding M-peptide containing the ALEEAN sequence. After UVB treatment T cell responses to all the M- and keratin peptides were abolished, while responses to the positive control antigen streptokinase/streptodornase (SK/SD) were not affected. These findings are consistent with the notion that aa sequences which keratin has in common with M-protein may be a major target for autoreactive T cells in psoriasis.
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- Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins.
- Authors: Sigmundsdottir H, Sigurgeirsson B, Troye-Blomberg M, Good MF, Valdimarsson H, Jonsdottir I
- Issue date: 1997 Jun
- Is psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin?
- Authors: Valdimarsson H, Sigmundsdóttir H, Jónsdóttir I
- Issue date: 1997 Jan
- Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells.
- Authors: Johnston A, Gudjonsson JE, Sigmundsdottir H, Love TJ, Valdimarsson H
- Issue date: 2004 Oct
- CD4+ T-cells from peripheral blood of a patient with psoriasis recognize keratin 14 peptide but not 'homologous' streptococcal M-protein epitope.
- Authors: Kobayashi H, Takahashi M, Takahashi H, Ishida-Yamamoto A, Hashimoto Y, Sato K, Tateno M, Iizuka H
- Issue date: 2002 Dec
- HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.
- Authors: Shen Z, Wang G, Fan JY, Li W, Liu YF
- Issue date: 2005 Apr