• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Gislason, Thorarinn
Johannsson, Johann Heidar
Haraldsson, Asgeir
Olafsdottir, Berglind Ran
Jonsdottir, Helga
Kong, Augustine
Frigge, Michael L
Jonsdottir, Guthrun M
Hakonarson, Hakon
Gulcher, Jeffrey
Stefansson, Kari
Show allShow less
Issue Date
2002-09-15

Metadata
Show full item record
Citation
Am. J. Respir. Crit. Care Med. 2002, 166(6):833-8
Abstract
Previous studies suggest a familial link between adult obstructive sleep apnea syndrome (OSAS) and sudden infant death syndrome (SIDS). However, most of these studies were hampered by the availability of too few cases of SIDS to draw conclusions. To examine the familial nature of this association in Iceland, hospital-based lists of all patients who were diagnosed with OSAS (n = 2,350) and SIDS (n = 58) from 1979 to 1998 were used to separately determine the familial occurrence of OSAS and SIDS and to search for evidence of cosegregation of these conditions in Icelandic families, using a nationwide genealogy database. The risk ratio for a first-degree relative of a patient with OSAS was 2.0 (1.7-2.8, 95% confidence interval). The risk ratio of the more severely affected patients with OSAS was slightly higher (2.3). Likewise, the kinship coefficient (KC) for the OSAS patient group, which determines the relatedness of the patients, was significantly larger than the mean KC of 1,000 matched control groups. Estimation of the KC for the SIDS group showed a trend toward significance when compared with control groups, but after excluding one of the half-siblings in the SIDS group from the analysis, the difference did not show any trend toward significance. Although the results of the analysis of the relatedness between all patients with OSAS and infants who died of SIDS were not significant, a trend toward significance was evident when the data were separately analyzed for the more severely affected patients with OSAS. Collectively, these results demonstrate a strong familial component in OSAS and suggest that infants who died of SIDS may have shared some of the same susceptibility factors with OSAS.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links
http://ajrccm.atsjournals.org/cgi/content/abstract/166/6/833
ae974a485f413a2113503eed53cd6c53
10.1164/rccm.2107121
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Obstructive sleep apnea in infants: relation to family history of sudden infant death syndrome, apparent life-threatening events, and obstructive sleep apnea.
  • Authors: McNamara F, Sullivan CE
  • Issue date: 2000 Mar
  • Bedsharing and maternal smoking in a population-based survey of new mothers.
  • Authors: Lahr MB, Rosenberg KD, Lapidus JA
  • Issue date: 2005 Oct
  • Use of a fan during sleep and the risk of sudden infant death syndrome.
  • Authors: Coleman-Phox K, Odouli R, Li DK
  • Issue date: 2008 Oct
  • Factors potentiating the risk of sudden infant death syndrome associated with the prone position.
  • Authors: Ponsonby AL, Dwyer T, Gibbons LE, Cochrane JA, Wang YG
  • Issue date: 1993 Aug 5
  • Is Tourette syndrome a cause of sudden infant death syndrome and childhood obstructive sleep apnea?
  • Authors: Sverd J, Montero G
  • Issue date: 1993 Jun 15

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.