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Serum thyroglobulin as a risk factor for thyroid carcinoma

dc.contributor.authorHrafnkelsson, J
dc.contributor.authorTulinius, H
dc.contributor.authorKjeld, M
dc.contributor.authorSigvaldason, H
dc.contributor.authorJonasson, J G
dc.date.accessioned2009-01-12T10:02:09Z
dc.date.available2009-01-12T10:02:09Z
dc.date.issued2000
dc.date.submitted2009-01-12
dc.identifier.citationActa Oncol. 2000, 39 8):973-7en
dc.identifier.issn0284-186X
dc.identifier.pmid11207005
dc.identifier.doi10.1080/02841860050215963
dc.identifier.urihttp://hdl.handle.net/2336/47295
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSamples from a biological serum bank taken up to 23 years prior to diagnosis of thyroid carcinoma were analysed for human thyroglobulin, thyroid-stimulating hormone and thyroxin. After exclusions, the final study material consisted of 59 cases of papillary and follicular carcinomas. These cases were compared with 164 controls, matched for sex, age and time of sample taking. The most interesting finding was that concentrations of thyroglobulin in serum were abnormally elevated in cases compared with controls, equal to or above 30 microg/L, with odds ratio 7.0 (CI 3.1-15.7). This elevation of serum thyroglobulin occurred in 44% of the carcinoma cases. Sensitivity was around 50 for measurements taken up to 15 years prior to diagnosis, but 21 when the interval was over 15 years. Specificity was 89. No differences were found between cases and controls in values for thyroid-stimulating hormone and thyroxin.
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=4024891&site=ehost-liveen
dc.subject.meshAdenocarcinoma, Follicularen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshCarcinoma, Papillaryen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLogistic Modelsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshRisk Factorsen
dc.subject.meshThyroglobulinen
dc.subject.meshThyroid Neoplasmsen
dc.subject.meshThyrotropinen
dc.subject.meshThyroxineen
dc.titleSerum thyroglobulin as a risk factor for thyroid carcinomaen
dc.typeArticleen
dc.contributor.departmentDepartment of Oncology, National University Hospital, Reykjavik, Iceland. jonhr@rsp.isen
dc.identifier.journalActa oncologica (Stockholm, Sweden)en
html.description.abstractSamples from a biological serum bank taken up to 23 years prior to diagnosis of thyroid carcinoma were analysed for human thyroglobulin, thyroid-stimulating hormone and thyroxin. After exclusions, the final study material consisted of 59 cases of papillary and follicular carcinomas. These cases were compared with 164 controls, matched for sex, age and time of sample taking. The most interesting finding was that concentrations of thyroglobulin in serum were abnormally elevated in cases compared with controls, equal to or above 30 microg/L, with odds ratio 7.0 (CI 3.1-15.7). This elevation of serum thyroglobulin occurred in 44% of the carcinoma cases. Sensitivity was around 50 for measurements taken up to 15 years prior to diagnosis, but 21 when the interval was over 15 years. Specificity was 89. No differences were found between cases and controls in values for thyroid-stimulating hormone and thyroxin.


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