Decreased respiratory depression during emergence from anesthesia with sevoflurane/N2O than with sevoflurane alone
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationCan J Anaesth. 1999, 46(4):335-41
AbstractPURPOSE: To investigate ventilation and gas elimination during the emergence from inhalational anesthesia with controlled normoventilation with either sevoflurane/N2O or sevoflurane alone. METHODS: Twenty-four ASA I-II patients scheduled for abdominal hysterectomy were randomly allocated to receive either 1.3 MAC sevoflurane/N2O (n = 12) or equi-MAC sevoflurane (n = 12) in 30% oxygen (O2). Expired minute ventilation volumes (V(E)), end-tidal (ET) concentrations of O2, carbon dioxide (CO2), sevoflurane and N2O as well as pulse oximetry saturation (SpO2) and CO2 elimination rates (VCO2) were measured. The ET concentrations of sevoflurane and N2O were converted to total MAC values and gas elimination was expressed in terms of MAC reduction. Time to resumption of spontaneous breathing and extubation were recorded and arterial blood gas analysis was performed at the end of controlled normoventilation and at the beginning of spontaneous breathing. RESULTS: Resumption of spontaneous breathing and extubation were 8 and 13 min less, respectively, in the sevoflurane/N2O than in the sevoflurane group. Spontaneous breathing was resumed in both groups when pH had decreased by 0.07-0.08 and PaCO2 increased by 1.3-1.5 kPa. Depression of V(E) and VCO2 were less, and MAC reduction more rapid in the sevoflurane/N2O than in the sevoflurane group. CONCLUSIONS: Respiratory recovery was faster after sevoflurane/N2O than sevoflurane anesthesia. Changes in pH and PaCO2 rather than absolute values were important for resumption of spontaneous breathing after controlled normoventilation. In both groups, the tracheas were extubated at about 0.2 MAC.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Respiration during emergence from anaesthesia with desflurane/N2O vs. desflurane/air for gynaecological laparoscopy.
- Authors: Einarsson SG, Cerne A, Bengtsson A, Stenqvist O, Bengtson JP
- Issue date: 1998 Nov
- Patient outcomes with positive pressure versus spontaneous ventilation in non-paralysed adults with the laryngeal mask.
- Authors: Keller C, Sparr HJ, Luger TJ, Brimacombe J
- Issue date: 1998 Jun
- Nitrous oxide diffusion and the second gas effect on emergence from anesthesia.
- Authors: Peyton PJ, Chao I, Weinberg L, Robinson GJ, Thompson BR
- Issue date: 2011 Mar
- Xenon provides faster emergence from anesthesia than does nitrous oxide-sevoflurane or nitrous oxide-isoflurane.
- Authors: Goto T, Saito H, Shinkai M, Nakata Y, Ichinose F, Morita S
- Issue date: 1997 Jun
- Comparison of three techniques for induction of anaesthesia with sevoflurane in children.
- Authors: Dubois MC, Piat V, Constant I, Lamblin O, Murat I
- Issue date: 1999