Corticotropin-induced reduction of plasma lipoprotein(a) concentrations in healthy individuals and hemodialysis patients: relation to apolipoprotein(a) size polymorphism
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationMetab. Clin. Exp. 1999, 48(3):342-6
AbstractLipoprotein(a) [Lp(a)], a strong independent cardiovascular risk factor, consists of the unique apolipoprotein(a) [apo(a)] covalently linked to a low-density lipoprotein particle. Apo(a) contains a widely differing number of the plasminogen-like kringle IV, a size polymorphism that is codominantly inherited. In addition to powerful genetic control, renal failure is known to influence the plasma Lp(a) concentration. There is still a lot to be learned about the mode and site of catabolism of Lp(a), and there is no readily applicable Lp(a)-lowering treatment available. Therefore, it was of interest to study further the Lp(a)-lowering effect of corticotropin (ACTH) that has been demonstrated in small studies. The main purpose of the present study was to investigate the influence of ACTH on different apo(a) isoforms. Short-term treatment with ACTH decreased the plasma Lp(a) concentration in all 26 study participants. The two study groups (12 healthy individuals and 14 hemodialysis patients) responded similarly, with a median decrease in plasma Lp(a) of 39% and 49%, respectively. In subjects with two clearly separable apo(a) bands, apo(a) phenotyping and densitometric scanning of the bands before and after treatment with ACTH revealed a change in the proportion of apo(a) isoforms, ie, a shift toward the isoform with lower molecular weight. This was observed in seven of nine investigated subjects (four of five healthy individuals and three of four hemodialysis patients).
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Pentanucleotide repeat and size polymorphisms in the apolipoprotein(a) gene are associated with the lipoprotein(a) concentration in chronic hemodialysis patients.
- Authors: Tanaka M, Yanagi H, Ando R, Kurihara S, Hirano C, Kobayashi K, Kikuchi S, Hamaguchi H, Tsuchiya S, Tomura S
- Issue date: 1999
- Apo(a) phenotypes and lp(a) concentrations in renal transplant patients.
- Authors: Kandoussi AM, Hugue V, Cachera C, Hazzan M, Dracon M, Tacquet A, Noël C
- Issue date: 1998 Oct
- Relationship between apo(a) length polymorphism and lipoprotein(a) concentration in healthy Ivorian subjects with single or double apo(a) isoforms.
- Authors: Edjème-Aké A, Garnotel R, Vallée-Polneau S, Anglés-Cano E, Monnet D, Gillery P
- Issue date: 2008 Sep
- Genomic structure and organization of kringles type 3 to 10 of the apolipoprotein(a) gene in 6q26-27.
- Authors: Mihalich A, Magnaghi P, Sessa L, Trubia M, Acquati F, Taramelli R
- Issue date: 1997 Sep 1
- LPA gene: interaction between the apolipoprotein(a) size ('kringle IV' repeat) polymorphism and a pentanucleotide repeat polymorphism influences Lp(a) lipoprotein level.
- Authors: Røsby O, Berg K
- Issue date: 2000 Jan