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Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheumatoid arthritis

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Authors
Jonsson, T
Steinsson, K
Jonsson, H
Geirsson, A J
Thorsteinsson, J
Valdimarsson, H
Útgáfudagur
1998-10-01

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Rheumatol. Int. 1998, 18(3):119-22
Útdráttur
The diagnostic value of measuring rheumatoid factor (RF) by agglutination or isotype-specific enzyme-linked immunosorbent assay (ELISA) was compared. The study included 70 patients with rheumatoid arthritis (RA) and 205 patients with various other rheumatic conditions. Of the RA patients, 74% were RF-positive by agglutination and 90% had one or more RF isotypes elevated by ELISA compared to 14% and 22%, respectively, of the other patients. Strikingly, 70% of the RF-positive RA patients had an elevation of two or more RF isotypes compared to only 16% of the other RF-positive patients (P < 0.0001). Furthermore, a combined elevation of IgM and IgA RF was found in 52% of the RF-positive RA patients, but only in two (4%) of the other RF-positive patients (P < 0.0001). It is concluded that a combined elevation of IgM and IgA RF is highly specific for RA and is very rarely found in rheumatic diseases other than RA. Isotype-specific RF assays are therefore diagnostically superior to agglutination tests. The detection of the RA-specific RF isotype pattern may be particularly helpful early in the course of RA even before the disease is fully differentiated.
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http://www.springerlink.com/content/14d5h6m2c1eev11m
ae974a485f413a2113503eed53cd6c53
10.1007/s002960050069
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English Journal Articles (Peer Reviewed)

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