Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels
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AuthorsPedersen, Daniella Bach
Koch Jensen, Peter
la Cour, Morten
Kiilgaard, Jens Folke
Wiencke, Anne Kathrine
MetadataShow full item record
CitationGraefes Arch. Clin. Exp. Ophthalmol. 2005, 243(2):163-8
AbstractBACKGROUND: Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig. We propose that they also raise the oxygen tension in the retina. We studied the oxygen tension in the pig retina and optic nerve before and after dorzolamide injection. Also the retinal vessel diameters during carbonic anhydrase inhibition were studied. METHODS: A polarographic oxygen electrode was placed transvitreally immediately over the retina or the optic disc in anaesthetised pigs. The oxygen tension was recorded continually and 500 mg dorzolamide was injected intravenously. Retinal vessel diameters were analysed from monochromatic fundus photographs taken before and after injection of dorzolamide. RESULTS: Baseline retinal oxygen tension (RPO2) was 3.34+/-0.50 kPa (mean +/- SD, n=6) and baseline optic nerve oxygen tension (ONPO2) was 3.63+/-1.00 kPa. RPO2 was increased by 0.36+/-0.11 kPa (n=6, P=0.025) and ONPO2 by 0.73+/-0.34 kPa (n=6, P=0.003) 30 min after dorzolamide administration. The retinal arterioles was significantly dilated by 13+/-7% (n=5, P=0.016) and the retinal venules by 12+/-8% (n=5, P=0.030) 30 min after injection of dorzolamide. CONCLUSION: Retinal and optic nerve oxygen tension increased with systemic administration of dorzolamide. The retinal vessels dilated, probably causing increased blood flow inducing the observed increase in RPO2. The increased oxygenation of retina by CAI may offer therapeutic possibilities in ischaemic diseases of the retina and optic nerve.
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- Optic nerve pH and PO2: the effects of carbonic anhydrase inhibition, and metabolic and respiratory acidosis.
- Authors: Pedersen DB, Stefánsson E, Kiilgaard JF, Jensen PK, Eysteinsson T, Bang K, la Cour M
- Issue date: 2006 Aug
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- Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide.
- Authors: la Cour M, Kiilgaard JF, Eysteinsson T, Wiencke AK, Bang K, Dollerup J, Jensen PK, Stefánsson E
- Issue date: 2000 Sep