The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Smith, A V
Hafsteinsdottir, S H
Launer, L J
Harris, T B
MetadataShow full item record
CitationInt J Obes (Lond). 2009, 33(2):267-72
AbstractOBJECTIVE: Common diseases often have an inflammatory component reflected by associated markers such as serum C-reactive protein (CRP) levels. Circulating CRP levels have also been associated with adipose tissue as well as with specific CRP genotypes. We examined the interaction between measures of body mass index (BMI), waist circumference and fat percent (total fat measured by bioimpedance) with genotypes of the CRP gene in the determination of CRP levels. METHODS: The first 2296 participants (mean age 76+/-6 years, 42% men) in the Age, Gene/Environment Susceptibility-Reykjavik Study, a multidisciplinary epidemiological study to determine risk factors in aging, were genotyped for 10 single nucleotide polymorphisms (SNPs) in the CRP gene. General linear models with age and terms for interaction of CRP genotypes with BMI, waist circumference and percent fat were used to evaluate the association of genotypes to CRP levels (high-sensitivity method, range 0-10 mg l(-1)) in men and women separately. RESULTS: We focused on the SNP rs1205 that represents the allele that captures the strongest effects of the gene on CRP levels. Carriers of the rs1205 G allele had significantly higher CRP levels than noncarriers in a dose-dependent manner. Compared to the AA genotype, the slope of the increase in CRP with increasing BMI (P=0.045) and waist circumference (P=0.014) was different for the G allele carriers and of similar magnitude in both men and women. The rs1205 interactions were not significant for fat mass percent, suggesting a possible association with fat localization. CONCLUSIONS: This study further illuminates the known association between measures of adiposity and CRP levels and is shown to be dependent on variation in the rs1205 SNP of the CRP gene. The correlated increase in CRP levels with adiposity is accentuated by presence of the G allele.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Association between C-reactive protein and adiposity in women.
- Authors: Bochud M, Marquant F, Marques-Vidal PM, Vollenweider P, Beckmann JS, Mooser V, Paccaud F, Rousson V
- Issue date: 2009 Oct
- A variant in the LRRFIP1 gene is associated with adiposity and inflammation.
- Authors: Plourde M, Vohl MC, Bellis C, Carless M, Dyer T, Dolley G, Marette A, Després JP, Bouchard C, Blangero J, Pérusse L
- Issue date: 2013 Jan
- Low-grade inflammation markers in children and adolescents: Influence of anthropometric characteristics and CRP and IL6 polymorphisms.
- Authors: Todendi PF, Possuelo LG, Klinger EI, Reuter CP, Burgos MS, Moura DJ, Fiegenbaum M, Valim AR
- Issue date: 2016 Dec
- Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study.
- Authors: Almeida OP, Norman PE, Allcock R, van Bockxmeer F, Hankey GJ, Jamrozik K, Flicker L
- Issue date: 2009 Aug
- Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference.
- Authors: Ankarfeldt MZ, Larsen SC, Ängquist L, Husemoen LL, Roswall N, Overvad K, Jakobsen MU, Halkjær J, Tjønneland A, Linneberg A, Toft U, Hansen T, Pedersen O, Heitmann BL, Astrup A, Sørensen TI
- Issue date: 2014