Is smoking an independent risk factor for invasive cervical cancer? A nested case-control study within Nordic biobanks
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsKapeu, Aline Simen
MetadataShow full item record
CitationAm. J. Epidemiol. 2009, 169(4):480-8
AbstractThe strong correlation between smoking and exposure to oncogenic human papillomaviruses (HPVs) has made it difficult to verify the independent role of smoking in cervical carcinogenesis. Thus, the authors evaluated this role. Five large Nordic serum banks containing samples from more than 1,000,000 subjects were linked with nationwide cancer registries (1973-2003). Serum samples were retrieved from 588 women who developed invasive cervical cancer and 2,861 matched controls. The samples were analyzed for cotinine (a biomarker of tobacco exposure) and antibodies to HPV types 16 and 18, herpes simplex virus type 2, and Chlamydia trachomatis. Smoking was associated with the risk of squamous cell carcinoma (SCC) among HPV16- and/or HPV18-seropositive heavy smokers (odds ratio=2.7, 95% confidence interval: 1.7, 4.3). A similar risk of SCC (odds ratio=3.2, 95% confidence interval: 2.6, 4.0) was found in heavy smokers after adjustment for HPV16/18 antibodies. The point estimates increased with increasing age at diagnosis and increasing cotinine level. This study confirms that smoking is an independent risk factor for cervical cancer/SCC in women infected with oncogenic HPVs. These findings emphasize the importance of cervical cancer prevention among women exposed to tobacco smoke.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Prospective seroepidemiologic study of human papillomavirus and other risk factors in cervical cancer.
- Authors: Arnheim Dahlström L, Andersson K, Luostarinen T, Thoresen S, Ögmundsdottír H, Tryggvadottír L, Wiklund F, Skare GB, Eklund C, Sjölin K, Jellum E, Koskela P, Wadell G, Lehtinen M, Dillner J
- Issue date: 2011 Dec
- Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck.
- Authors: Mork J, Lie AK, Glattre E, Hallmans G, Jellum E, Koskela P, Møller B, Pukkala E, Schiller JT, Youngman L, Lehtinen M, Dillner J
- Issue date: 2001 Apr 12
- Lack of association between human papillomavirus type 16 and 18 infections and female lung cancer.
- Authors: Simen-Kapeu A, Surcel HM, Koskela P, Pukkala E, Lehtinen M
- Issue date: 2010 Jul
- A prospective, seroepidemiological study of the role of human papillomavirus in esophageal cancer in Norway.
- Authors: Bjørge T, Hakulinen T, Engeland A, Jellum E, Koskela P, Lehtinen M, Luostarinen T, Paavonen J, Sapp M, Schiller J, Thoresen S, Wang Z, Youngman L, Dillner J
- Issue date: 1997 Sep 15
- Joint effect of HPV16 with Chlamydia trachomatis and smoking on risk of cervical cancer: antagonism or misclassification (Nordic countries).
- Authors: Hakama M, Luostarinen T, Hallmans G, Jellum E, Koskela P, Lehtinen M, Thoresen S, Youngman L, Hakulinen T
- Issue date: 2000 Oct