Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Rudenko, Iakov N
Kalia, Suneil K
Kalia, Lorraine V
Nalls, Mike A
Hauser, David N
Lozano, Andres M
Greene, Lois E
Cookson, Mark R
MetadataShow full item record
CitationProc. Natl. Acad. Sci. U.S.A. 2014, 111 (7):2626-31
AbstractMutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein-protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G-associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for sporadic PD identified by genome-wide association studies. These proteins form a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system both in vitro and in vivo. We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms.
DescriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.
RightsArchived with thanks to Proceedings of the National Academy of Sciences of the United States of America
- Pathway for Parkinson disease.
- Authors: Hoang QQ
- Issue date: 2014 Feb 18
- RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.
- Authors: MacLeod DA, Rhinn H, Kuwahara T, Zolin A, Di Paolo G, McCabe BD, Marder KS, Honig LS, Clark LN, Small SA, Abeliovich A
- Issue date: 2013 Feb 6
- LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.
- Authors: Gómez-Suaga P, Rivero-Ríos P, Fdez E, Blanca Ramírez M, Ferrer I, Aiastui A, López De Munain A, Hilfiker S
- Issue date: 2014 Dec 20
- Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.
- Authors: Cookson MR
- Issue date: 2016 Dec 15
- Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
- Authors: Trancikova A, Mamais A, Webber PJ, Stafa K, Tsika E, Glauser L, West AB, Bandopadhyay R, Moore DJ
- Issue date: 2012