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dc.contributor.authorIftikhar, Imran H
dc.contributor.authorValentine, Christopher W
dc.contributor.authorBittencourt, Lia R A
dc.contributor.authorCohen, Debbie L
dc.contributor.authorFedson, Annette C
dc.contributor.authorGíslason, Thorarinn
dc.contributor.authorPenzel, Thomas
dc.contributor.authorPhillips, Craig L
dc.contributor.authorYu-sheng, Lin
dc.contributor.authorPack, Allan I
dc.contributor.authorMagalang, Ulysses J
dc.date.accessioned2015-05-04T11:40:22Zen
dc.date.available2015-05-04T11:40:22Zen
dc.date.issued2014-12en
dc.date.submitted2015en
dc.identifier.citationJ. Hypertens. 2014, 32 (12):2341-50; discussion 2350en
dc.identifier.issn1473-5598en
dc.identifier.pmid25243523en
dc.identifier.doi10.1097/HJH.0000000000000372en
dc.identifier.urihttp://hdl.handle.net/2336/552140en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractTo systematically analyze the studies that have examined the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with resistant hypertension and obstructive sleep apnea (OSA).
dc.description.abstractDesign - meta-analysis of observational studies and randomized controlled trials (RCTs) indexed in PubMed and Ovid (All Journals@Ovid). participants: individuals with resistant hypertension and OSA; interventions - CPAP treatment.
dc.description.abstractA total of six studies met the inclusion criteria for preintervention to postintervention analyses. The pooled estimates of mean changes after CPAP treatment for the ambulatory (24-h) SBP and DBP from six studies were -7.21 mmHg [95% confidence interval (CI): -9.04 to -5.38; P < 0.001; I² 58%) and -4.99 mmHg (95% CI: -6.01 to -3.96; P < 0.001; I² 31%), respectively. The pooled estimate of the ambulatory SBP and DBP from the four RCTs showed a mean net change of -6.74 mmHg [95% CI: -9.98 to -3.49; P < 0.001; I² 61%] and -5.94 mmHg (95% CI: -9.40 to -2.47; P = 0.001; I² 76%), respectively, in favor of the CPAP group.
dc.description.abstractThe pooled estimate shows a favorable reduction of BP with CPAP treatment in patients with resistant hypertension and OSA. The effects sizes are larger than those previously reported in patients with OSA without resistant hypertension.
dc.description.sponsorshipNHLBI award P01 HL094307 (A.I.P.), HL093463 (U.J.M.) and UL1TR000090 of the Ohio State University Center for Clinical and Translational Science.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://dx.doi.org/ 10.1097/HJH.0000000000000372en
dc.relation.urlhttp://ovidsp.uk.ovid.com/sp-3.15.1b/ovidweb.cgi?WebLinkFrameset=1&S=AAKHPDHKGPHFILPLFNKKBAAGONACAA00&returnUrl=ovidweb.cgi%3f%26Full%2bText%3dL%257cS.sh.22.23%257c0%257c00004872-201412000-00007%26S%3dAAKHPDHKGPHFILPLFNKKBAAGONACAA00&directlink=http%3a%2f%2fgraphics.uk.ovid.com%2fovftpdfs%2fPDHFFNAGBAPLGP00%2ffs046%2fovft%2flive%2fgv023%2f00004872%2f00004872-201412000-00007.pdf&filename=Effects+of+continuous+positive+airway+pressure+on+blood+pressure+in+patients+with+resistant+hypertension+and+obstructive+sleep+apnea%3a++a+meta-analysis.&pdf_key=PDHFFNAGBAPLGP00&pdf_index=/fs046/ovft/live/gv023/00004872/00004872-201412000-00007en
dc.rightsArchived with thanks to Journal of hypertensionen
dc.subjectKæfisvefnen
dc.subjectHáþrýstinguren
dc.subject.meshSleep Apnea, Obstructiveen
dc.subject.meshBlood Pressureen
dc.subject.meshHypertensionen
dc.subject.meshContinuous Positive Airway Pressureen
dc.subject.meshMeta-Analysis [Publication Type]en
dc.titleEffects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis.en
dc.typeArticleen
dc.contributor.departmentDivision of Pulmonary, Critical Care, and Sleep Medicine, University of South Carolina, Columbia, South Carolina bDivision of Nephrology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA cDisciplina de Medicina e Biologia do Sono, Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil dRenal and Hypertension Division, University of Pennsylvania Perelman School of Medicine eDivision of Sleep Medicine, Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA fFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland gCenter of Sleep Medicine, Charité University Hospital, Berlin, Germany hDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards iWoodcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia jDepartment of Internal Medicine, Taoyuan Chang Gung Memorial Hospital, Taiwan, Republic of China kDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.en
dc.identifier.journalJournal of hypertensionen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractTo systematically analyze the studies that have examined the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with resistant hypertension and obstructive sleep apnea (OSA).
html.description.abstractDesign - meta-analysis of observational studies and randomized controlled trials (RCTs) indexed in PubMed and Ovid (All Journals@Ovid). participants: individuals with resistant hypertension and OSA; interventions - CPAP treatment.
html.description.abstractA total of six studies met the inclusion criteria for preintervention to postintervention analyses. The pooled estimates of mean changes after CPAP treatment for the ambulatory (24-h) SBP and DBP from six studies were -7.21 mmHg [95% confidence interval (CI): -9.04 to -5.38; P < 0.001; I² 58%) and -4.99 mmHg (95% CI: -6.01 to -3.96; P < 0.001; I² 31%), respectively. The pooled estimate of the ambulatory SBP and DBP from the four RCTs showed a mean net change of -6.74 mmHg [95% CI: -9.98 to -3.49; P < 0.001; I² 61%] and -5.94 mmHg (95% CI: -9.40 to -2.47; P = 0.001; I² 76%), respectively, in favor of the CPAP group.
html.description.abstractThe pooled estimate shows a favorable reduction of BP with CPAP treatment in patients with resistant hypertension and OSA. The effects sizes are larger than those previously reported in patients with OSA without resistant hypertension.


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