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dc.contributor.authorJørgensen, Christina M
dc.contributor.authorHardarson, Sveinn H
dc.contributor.authorBek, Toke
dc.date.accessioned2015-05-05T10:35:48Zen
dc.date.available2015-05-05T10:35:48Zen
dc.date.issued2014-02en
dc.date.submitted2015en
dc.identifier.citationActa Ophthalmol. 2014, 92 (1):34-9en
dc.identifier.issn1755-3768en
dc.identifier.pmid24330421en
dc.identifier.doi10.1111/aos.12283en
dc.identifier.urihttp://hdl.handle.net/2336/552289en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractDiabetic retinopathy is characterized by morphological lesions in the retina secondary to disturbances in retinal blood flow which may influence the supply of oxygen to the retinal metabolism. Using retinal oximetry, it has been shown that the oxygen saturation is increased in retinal arterioles and venules from diabetic patients with retinopathy, but oxygenation before the development of retinopathy and possible differences in retinal oxygenation between diabetic maculopathy and proliferative diabetic retinopathy patients have not been evaluated.
dc.description.abstractOne-hundred and fifty-six consecutive patients referred for specialist evaluation of diabetic retinopathy, and eighty normal control persons were subjected to retinal oximetry of the larger retinal arterioles and venules. The diabetic patients were allocated to one of four groups with severity of retinopathy ranging from no retinopathy to vision-threatening retinopathy, and the oxygen saturation in arterioles and venules was compared between these groups.
dc.description.abstractIncreasing severity of retinal changes from no retinopathy to diabetic maculopathy was accompanied with increasing oxygen saturation in retinal venules and decreasing oxygen extraction, whereas proliferative diabetic retinopathy showed increased oxygen saturation in both retinal arterioles and venules to result in a normal oxygen extraction.
dc.description.abstractProspective observational and interventional studies are needed to show whether changes in retinal oxygen saturation precede or follow the development of diabetic retinopathy. Additionally, studies of regional variations in haemodynamic parameters in patients with vision-threatening diabetic retinopathy might improve the understanding of the pathophysiology of diabetic retinopathy. This is a precondition for improving the prevention and treatment of the disease.
dc.description.sponsorshipVELUX Foundationen
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/ 10.1111/aos.12283en
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aos.12283/epdfen
dc.rightsArchived with thanks to Acta ophthalmologicaen
dc.subjectSykursýkien
dc.subjectAugnsjúkdómaren
dc.subject.meshAdulten
dc.subject.meshBlood Glucoseen
dc.subject.meshBlood Pressureen
dc.subject.meshDiabetes Mellitus, Type 1en
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshDiabetic Retinopathyen
dc.subject.meshFemaleen
dc.subject.meshHemoglobin A, Glycosylateden
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOximetryen
dc.subject.meshOxygenen
dc.subject.meshOxygen Consumptionen
dc.subject.meshRegional Blood Flowen
dc.subject.meshRetinal Arteryen
dc.subject.meshRetinal Veinen
dc.titleThe oxygen saturation in retinal vessels from diabetic patients depends on the severity and type of vision-threatening retinopathy.en
dc.typeArticleen
dc.contributor.departmentAarhus Univ Hosp, Dept Ophthalmol, DK-8000 Aarhus C, Denmark, Univ Iceland, Dept Ophthalmol, Reykjavik, Icelanden
dc.identifier.journalActa ophthalmologicaen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractDiabetic retinopathy is characterized by morphological lesions in the retina secondary to disturbances in retinal blood flow which may influence the supply of oxygen to the retinal metabolism. Using retinal oximetry, it has been shown that the oxygen saturation is increased in retinal arterioles and venules from diabetic patients with retinopathy, but oxygenation before the development of retinopathy and possible differences in retinal oxygenation between diabetic maculopathy and proliferative diabetic retinopathy patients have not been evaluated.
html.description.abstractOne-hundred and fifty-six consecutive patients referred for specialist evaluation of diabetic retinopathy, and eighty normal control persons were subjected to retinal oximetry of the larger retinal arterioles and venules. The diabetic patients were allocated to one of four groups with severity of retinopathy ranging from no retinopathy to vision-threatening retinopathy, and the oxygen saturation in arterioles and venules was compared between these groups.
html.description.abstractIncreasing severity of retinal changes from no retinopathy to diabetic maculopathy was accompanied with increasing oxygen saturation in retinal venules and decreasing oxygen extraction, whereas proliferative diabetic retinopathy showed increased oxygen saturation in both retinal arterioles and venules to result in a normal oxygen extraction.
html.description.abstractProspective observational and interventional studies are needed to show whether changes in retinal oxygen saturation precede or follow the development of diabetic retinopathy. Additionally, studies of regional variations in haemodynamic parameters in patients with vision-threatening diabetic retinopathy might improve the understanding of the pathophysiology of diabetic retinopathy. This is a precondition for improving the prevention and treatment of the disease.


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