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dc.contributor.authorShao, Yangzhen
dc.contributor.authorRedfors, Bjorn
dc.contributor.authorBenoist, David
dc.contributor.authorGizurarson, Sigfus
dc.contributor.authorOmerovic, Elmir
dc.date.accessioned2015-05-11T16:31:06Zen
dc.date.available2015-05-11T16:31:06Zen
dc.date.issued2014-08en
dc.date.submitted2015en
dc.identifier.citationMol. Cell. Biochem. 2014, 393 (1-2):191-7en
dc.identifier.issn1573-4919en
dc.identifier.pmid24771065en
dc.identifier.doi10.1007/s11010-014-2060-0en
dc.identifier.urihttp://hdl.handle.net/2336/552624en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractArrhythmias have been treated for a long time with drugs that mainly target the ionic pumps and channels. These anti-arrhythmic regimens per se introduce new arrhythmias, which can be detrimental to patients. Advances in development of novel pharmacology without introduction of iatrogenic arrhythmias are thus favorable for an effective treatment of arrhythmias. Electrophysiological stability of the heart has been shown to be closely associated with cardiac metabolism. The present effective anti-arrhythmic drugs such as beta-blockers and amiodarone have profound beneficial effects in regulating myocardial metabolism. Aiming at decreasing production of toxic metabolites or preventing accumulation of arrhythmogenic lipids perhaps is a good strategy to effectively control arrhythmias. Therefore, a better understanding of the pro-arrhythmic profiles of cardiac metabolites helps to explore a new generation of metabolically oriented anti-arrhythmic medications. In this review, we present several lipid metabolites and summarize their arrhythmogenic characteristics.
dc.description.sponsorshipAFA insurance Swedish Heart and Lung Foundation Swedish Scientific Research Council University of Gothenburg, Swedenen
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://dx.doi.org/ 10.1007/s11010-014-2060-0en
dc.relation.urlhttp://download-v2.springer.com/static/pdf/30/art%253A10.1007%252Fs11010-014-2060-0.pdf?token2=exp=1431362858~acl=%2Fstatic%2Fpdf%2F30%2Fart%25253A10.1007%25252Fs11010-014-2060-0.pdf*~hmac=d8ad991dd691ce032bbbd73410cf321ca53a6d9ea390eaee50b77069120ecba0en
dc.rightsArchived with thanks to Molecular and cellular biochemistryen
dc.subject.meshAdrenergic beta-Antagonistsen
dc.subject.meshAnti-Arrhythmia Agentsen
dc.subject.meshArrhythmias, Cardiacen
dc.subject.meshCeramidesen
dc.subject.meshFatty Acids, Nonesterifieden
dc.subject.meshHumansen
dc.subject.meshLipid Metabolismen
dc.subject.meshLysophosphatidylcholinesen
dc.subject.meshMolecular Targeted Therapyen
dc.subject.meshPalmitoylcarnitineen
dc.titleLipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology.en
dc.typeArticleen
dc.contributor.departmentUniv Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden, Univ Bordeaux, INSERM, U1045, Ctr Rech Cardiothorac,LIRYC, Bordeaux, Franceen
dc.identifier.journalMolecular and cellular biochemistryen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractArrhythmias have been treated for a long time with drugs that mainly target the ionic pumps and channels. These anti-arrhythmic regimens per se introduce new arrhythmias, which can be detrimental to patients. Advances in development of novel pharmacology without introduction of iatrogenic arrhythmias are thus favorable for an effective treatment of arrhythmias. Electrophysiological stability of the heart has been shown to be closely associated with cardiac metabolism. The present effective anti-arrhythmic drugs such as beta-blockers and amiodarone have profound beneficial effects in regulating myocardial metabolism. Aiming at decreasing production of toxic metabolites or preventing accumulation of arrhythmogenic lipids perhaps is a good strategy to effectively control arrhythmias. Therefore, a better understanding of the pro-arrhythmic profiles of cardiac metabolites helps to explore a new generation of metabolically oriented anti-arrhythmic medications. In this review, we present several lipid metabolites and summarize their arrhythmogenic characteristics.


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