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Changes in quality of life in the first 5 years of disease in a multicenter cohort of patients with systemic lupus erythematosus.

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Authors
Urowitz, M
Gladman, D D
Ibañez, D
Sanchez-Guerrero, J
Bae, S C
Gordon, C
Fortin, P R
Clarke, A
Bernatsky, S
Hanly, J G
Wallace, D J
Isenberg, D
Rahman, A
Merrill, J
Ginzler, E
Alarcón, G S
Fessler, B
Khamashta, M
Steinsson, K
Petri, M
Dooley, M
Bruce, I N
Manzi, S
Sturfelt, G
Nived, O
Ramsey-Goldman, R
Zoma, A
Maddison, P
Kalunian, K
van Vollenhoven, R
Aranow, C
Romero Diaz, J
Stoll, T
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Issue Date
2014-09

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Citation
Arthritis Care Res (Hoboken) 2014, 66 (9):1374-9
Abstract
The Medical Outcomes Study Short Form 36 (SF-36) is recommended to assess quality of life (QOL) in systemic lupus erythematosus (SLE). The aim of the current study was to assess QOL over time in the first 5 years of a multicenter inception cohort of patients with SLE.
An inception SLE cohort was assembled according to a standardized protocol between 2000 and 2012. In addition to clinical and laboratory assessments, patients completed the SF-36 at yearly intervals. Only patients who had ≥5 completed QOL questionnaires were included in these analyses. Generalized estimating equation models were run separately for each of the 8 subscales and for the physical and mental component summary scores, adjusting for repeated measures by patients.
A total of 495 patients were included. The mean ± SD disease duration at the first visit was 5.3 ± 4.1 months. The mean ± SD age at enrollment was 35.8 ± 13.2 years. All 8 subscales and the 2 summary scores showed improvement in the first 2 years from enrollment. Between years 2 and 5, none of the subscales or summary scores showed any change. Minimum clinically important improvement was achieved by 35-56% of the patients and was influenced by demographic and disease factors.
Unlike late-stage lupus, where QOL is stable over time, in patients with early disease, all subscales improve in early followup up to 2 years. Therefore, the SF-36 may be a sensitive outcome measure in early disease in patients with SLE.
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Additional Links
http://dx.doi.org/10.1002/acr.22299
http://onlinelibrary.wiley.com/doi/10.1002/acr.22299/epdf
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Archived with thanks to Arthritis care & research
ae974a485f413a2113503eed53cd6c53
10.1002/acr.22299
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English Journal Articles (Peer Reviewed)

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