A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.
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Rasmussen, Henrik B
Hartmann, Annette M
Mühleisen, Thomas W
Pietiläinen, Olli P H
Di Forti, Marta
Cantor, Rita M
Owen, Michael J
Andreassen, Ole A
Nöthen, Markus M
St Clair, David
Ophoff, Roel A
O'Donovan, Michael C
Collier, David A
MetadataShow full item record
CitationHum. Mol. Genet. 2010, 19 (7):1379-86
AbstractThe Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.
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- Issue date: 2010 Jul
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- Authors: Ren Z, Qiu A, Zhang A, Huang L, Rao S
- Issue date: 2016 Oct 6
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- AHI1, a pivotal neurodevelopmental gene, and C6orf217 are associated with susceptibility to schizophrenia.
- Authors: Amann-Zalcenstein D, Avidan N, Kanyas K, Ebstein RP, Kohn Y, Hamdan A, Ben-Asher E, Karni O, Mujaheed M, Segman RH, Maier W, Macciardi F, Beckmann JS, Lancet D, Lerer B
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- Support for involvement of the AHI1 locus in schizophrenia.
- Authors: Ingason A, Sigmundsson T, Steinberg S, Sigurdsson E, Haraldsson M, Magnusdottir BB, Frigge ML, Kong A, Gulcher J, Thorsteinsdottir U, Stefansson K, Petursson H, Stefansson H
- Issue date: 2007 Sep