A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.
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Authors
Ingason, AndrésGiegling, Ina
Cichon, Sven
Hansen, Thomas
Rasmussen, Henrik B
Nielsen, Jimmi
Jürgens, Gesche
Muglia, Pierandrea
Hartmann, Annette M
Strengman, Eric
Vasilescu, Catalina
Mühleisen, Thomas W
Djurovic, Srdjan
Melle, Ingrid
Lerer, Bernard
Möller, Hans-Jürgen
Francks, Clyde
Pietiläinen, Olli P H
Lonnqvist, Jouko
Suvisaari, Jaana
Tuulio-Henriksson, Annamari
Walshe, Muriel
Vassos, Evangelos
Di Forti, Marta
Murray, Robin
Bonetto, Chiara
Tosato, Sarah
Cantor, Rita M
Rietschel, Marcella
Craddock, Nick
Owen, Michael J
Peltonen, Leena
Andreassen, Ole A
Nöthen, Markus M
St Clair, David
Ophoff, Roel A
O'Donovan, Michael C
Collier, David A
Werge, Thomas
Rujescu, Dan
Issue Date
2010-04-01
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Hum. Mol. Genet. 2010, 19 (7):1379-86Abstract
The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.Additional Links
http://dx.doi.org/ 10.1093/hmg/ddq009http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838541/
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openAccessae974a485f413a2113503eed53cd6c53
10.1093/hmg/ddq009
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