Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease.
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Authors
Steinberg, StacyStefansson, Hreinn
Jonsson, Thorlakur
Johannsdottir, Hrefna
Ingason, Andres
Helgason, Hannes
Sulem, Patrick
Magnusson, Olafur Th
Gudjonsson, Sigurjon A
Unnsteinsdottir, Unnur
Kong, Augustine
Helisalmi, Seppo
Soininen, Hilkka
Lah, James J
Aarsland, Dag
Fladby, Tormod
Ulstein, Ingun D
Djurovic, Srdjan
Sando, Sigrid B
White, Linda R
Knudsen, Gun-Peggy
Westlye, Lars T
Selbæk, Geir
Giegling, Ina
Hampel, Harald
Hiltunen, Mikko
Levey, Allan I
Andreassen, Ole A
Rujescu, Dan
Jonsson, Palmi V
Bjornsson, Sigurbjorn
Snaedal, Jon
Stefansson, Kari
Issue Date
2015-05
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Nat. Genet. 2015, 47 (5):445-7Abstract
We conducted a search for rare, functional variants altering susceptibility to Alzheimer's disease that exploited knowledge of common variants associated with the same disease. We found that loss-of-function variants in ABCA7 confer risk of Alzheimer's disease in Icelanders (odds ratio (OR) = 2.12, P = 2.2 × 10(-13)) and discovered that the association replicated in study groups from Europe and the United States (combined OR = 2.03, P = 6.8 × 10(-15)).Additional Links
http://dx.doi.org/ 10.1038/ng.3246http://www.nature.com/ng/journal/v47/n5/pdf/ng.3246.pdf
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Archived with thanks to Nature geneticsae974a485f413a2113503eed53cd6c53
10.1038/ng.3246
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