Muscle Quality and Muscle Fat Infiltration in Relation to Incident Mobility Disability and Gait Speed Decline: the Age, Gene/Environment Susceptibility-Reykjavik Study.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Reinders, IlseMurphy, Rachel A
Koster, Annemarie
Brouwer, Ingeborg A
Visser, Marjolein
Garcia, Melissa E
Launer, Lenore J
Siggeirsdottir, Kristin
Eiriksdottir, Gudny
Jonsson, Palmi V
Gudnason, Vilmundur
Harris, Tamara B
Issue Date
2015-08
Metadata
Show full item recordCitation
J. Gerontol. A Biol. Sci. Med. Sci. 2015, 70 (8):1030-6Abstract
Aging is associated with increased risk of reduced mobility. However, data on muscle components in relation to subjective and objective indicators of disability is limited.Data were from 2,725 participants (43% men) aged 74.8±4.7 years from the AGES-Reykjavik Study. At baseline, maximal isometric thigh strength (dynamometer chair), and midthigh muscle area and muscle fat infiltration were assessed with computed tomography. Usual 6 m gait speed and mobility disability were assessed at baseline and after 5.2±0.3 years. Incident mobility disability was defined as having much difficulty or unable to walk 500 m or climb-up 10 steps. A decrease of ≥0.1 m/s in gait speed was considered clinically relevant.
Greater strength and area were protective for mobility disability risk and gait speed decline. After adjustment for other muscle components, greater strength was independently associated with lower mobility disability risk in women odds ratios (OR) 0.78 (95% CI 0.62, 0.99), and lower decline in gait speed risk among both men OR 0.64 (0.54, 0.76), and women OR 0.72 (0.62, 0.82). Larger muscle area was independently associated with lower mobility disability risk in women OR 0.67 (0.52, 0.87) and lower decline in gait speed risk in men OR 0.74 (0.61, 0.91).
Greater muscle strength and area were independently associated with 15-30% decreased risk of mobility disability in women and gait speed decline in men. Among women, greater muscle strength was also associated with lower risk of gait speed decline. Interventions aimed at maintaining muscle strength and area in old age might delay functional decline.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageAdditional Links
http://dx.doi.org/ 10.1093/gerona/glv016Rights
Archived with thanks to The journals of gerontology. Series A, Biological sciences and medical sciencesae974a485f413a2113503eed53cd6c53
10.1093/gerona/glv016
Scopus Count
Collections
Related articles
- Polyunsaturated fatty acids in relation to incident mobility disability and decline in gait speed; the Age, Gene/Environment Susceptibility-Reykjavik Study.
- Authors: Reinders I, Murphy RA, Song X, Visser M, Cotch MF, Lang TF, Garcia ME, Launer LJ, Siggeirsdottir K, Eiriksdottir G, Jonsson PV, Gudnason V, Harris TB, Brouwer IA
- Issue date: 2015 Apr
- Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study.
- Authors: Beavers KM, Beavers DP, Houston DK, Harris TB, Hue TF, Koster A, Newman AB, Simonsick EM, Studenski SA, Nicklas BJ, Kritchevsky SB
- Issue date: 2013 Mar
- Absolute strength and loss of strength as predictors of mobility decline in older adults: the InCHIANTI study.
- Authors: Hicks GE, Shardell M, Alley DE, Miller RR, Bandinelli S, Guralnik J, Lauretani F, Simonsick EM, Ferrucci L
- Issue date: 2012 Jan
- Gait Speed Predicts Incident Disability: A Pooled Analysis.
- Authors: Perera S, Patel KV, Rosano C, Rubin SM, Satterfield S, Harris T, Ensrud K, Orwoll E, Lee CG, Chandler JM, Newman AB, Cauley JA, Guralnik JM, Ferrucci L, Studenski SA
- Issue date: 2016 Jan
- Chronic kidney disease defined by cystatin C predicts mobility disability and changes in gait speed: the Framingham Offspring Study.
- Authors: Liu CK, Lyass A, Massaro JM, D'Agostino RB Sr, Fox CS, Murabito JM
- Issue date: 2014 Mar