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dc.contributor.authorvan Sloten, Thomas T
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorvan Buchem, Mark A
dc.contributor.authorPhillips, Caroline L
dc.contributor.authorJonsson, Palmi V
dc.contributor.authorDing, Jie
dc.contributor.authorSchram, Miranda T
dc.contributor.authorHarris, Tamara B
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorLauner, Lenore J
dc.date.accessioned2015-07-24T12:49:21Zen
dc.date.available2015-07-24T12:49:21Zen
dc.date.issued2015-06-01en
dc.date.submitted2015en
dc.identifier.citationAm J Psychiatry 2015, 172 (6):570-8en
dc.identifier.issn1535-7228en
dc.identifier.pmid25734354en
dc.identifier.doi10.1176/appi.ajp.2014.14050578en
dc.identifier.urihttp://hdl.handle.net/2336/560933en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractThe vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and depressive symptoms are scarce. The authors investigated the association between CSVD and incident depressive symptoms.
dc.description.abstractLongitudinal data were taken from the Age, Gene/Environment Susceptibility-Reykjavik Study of 1,949 participants free of dementia and without baseline depressive symptoms (mean age: 74.6 years [SD=4.6]; women, 56.6%). MRI markers of CSVD, detected at baseline (2002-2006) and follow-up (2007-2011), included white matter hyperintensity volume, subcortical infarcts, cerebral microbleeds, Virchow-Robin spaces, and total brain parenchyma volume. Incident depressive symptoms were defined by a score ≥6 on the 15-item Geriatric Depression Scale and/or use of antidepressant medication.
dc.description.abstractDepressive symptoms occurred in 10.1% of the participants. The association for a greater onset of depressive symptoms was significant for participants with 1 standard deviation increase in white matter hyperintensity volume over time, new subcortical infarcts, new Virchow-Robin spaces, 1 standard deviation lower total brain volume at baseline, and 1 standard deviation decreased total brain volume over time, after adjustments for cognitive function and sociodemographic and cardiovascular factors. Results were qualitatively similar when change in the Geriatric Depression Scale score over time was used as the outcome instead of incident depressive symptoms.
dc.description.abstractMost markers of progression of CSVD over time and some markers of baseline CSVD are associated with concurrently developing new depressive symptoms. These findings support the vascular depression hypothesis.
dc.description.sponsorshipAGES-Reykjavik Study - NIH N01-AG-12100 Intramural Research Program of the National Institute on Aging Icelandic Heart Association Icelandic Parliamenten
dc.language.isoenen
dc.publisherAmer Psychiatric Publishingen
dc.relation.urlhttp://dx.doi.org/ 10.1176/appi.ajp.2014.14050578en
dc.relation.urlhttp://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2014.14050578en
dc.rightsArchived with thanks to The American journal of psychiatryen
dc.subjectÞunglyndien
dc.subjectAldraðiren
dc.subjectHjarta- og æðasjúkdómaren
dc.subject.meshCerebral Cortexen
dc.subject.meshDepressionen
dc.subject.meshAgeden
dc.subject.meshVascular Diseasesen
dc.titleCerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study.en
dc.typeArticleen
dc.contributor.department[ 1 ] Maastricht Univ, Med Ctr, Dept Med, Cardiovasc Res Inst, NL-6200 MD Maastricht, Netherlands [ 2 ] Maastricht Univ, Med Ctr, Sch Nutr Toxicol & Metab, NL-6200 MD Maastricht, Netherlands [ 3 ] Iceland Heart Assoc, Kopavogur, Iceland [ 4 ] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands [ 5 ] NIA, Intramural Res Program, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA [ 6 ] Landspitali Univ Hosp, Dept Geriatr, Reykjavik, Iceland [ 7 ] Univ Iceland, Fac Med, Reykjavik, Icelanden
dc.identifier.journalThe American journal of psychiatryen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractThe vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and depressive symptoms are scarce. The authors investigated the association between CSVD and incident depressive symptoms.
html.description.abstractLongitudinal data were taken from the Age, Gene/Environment Susceptibility-Reykjavik Study of 1,949 participants free of dementia and without baseline depressive symptoms (mean age: 74.6 years [SD=4.6]; women, 56.6%). MRI markers of CSVD, detected at baseline (2002-2006) and follow-up (2007-2011), included white matter hyperintensity volume, subcortical infarcts, cerebral microbleeds, Virchow-Robin spaces, and total brain parenchyma volume. Incident depressive symptoms were defined by a score ≥6 on the 15-item Geriatric Depression Scale and/or use of antidepressant medication.
html.description.abstractDepressive symptoms occurred in 10.1% of the participants. The association for a greater onset of depressive symptoms was significant for participants with 1 standard deviation increase in white matter hyperintensity volume over time, new subcortical infarcts, new Virchow-Robin spaces, 1 standard deviation lower total brain volume at baseline, and 1 standard deviation decreased total brain volume over time, after adjustments for cognitive function and sociodemographic and cardiovascular factors. Results were qualitatively similar when change in the Geriatric Depression Scale score over time was used as the outcome instead of incident depressive symptoms.
html.description.abstractMost markers of progression of CSVD over time and some markers of baseline CSVD are associated with concurrently developing new depressive symptoms. These findings support the vascular depression hypothesis.


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