Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Boyer, Philip J
Carpenter, John E
Holmes, Dawn B
Bennett, Jeffrey L
Cohrs, Randall J
Eberhart, Charles G
Poppiti, Robert J
Tamhankar, Madhura A
Nagel, Maria A
MetadataShow full item record
CitationNeurology 2015, 84 (19):1948-55
AbstractVaricella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA).
Formalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies (50 sections/TA) including adjacent skeletal muscle and normal TAs obtained postmortem from subjects >50 years of age were examined by immunohistochemistry for presence and distribution of VZV antigen and by ultrastructural examination for virions. Adjacent regions were examined by hematoxylin & eosin staining. VZV antigen-positive slides were analyzed by PCR for VZV DNA.
VZV antigen was found in 61/82 (74%) GCA-positive TAs compared with 1/13 (8%) normal TAs (p < 0.0001, relative risk 9.67, 95% confidence interval 1.46, 63.69). Most GCA-positive TAs contained viral antigen in skip areas. VZV antigen was present mostly in adventitia, followed by media and intima. VZV antigen was found in 12/32 (38%) skeletal muscles adjacent to VZV antigen-positive TAs. Despite formalin fixation, VZV DNA was detected in 18/45 (40%) GCA-positive VZV antigen-positive TAs, in 6/10 (60%) VZV antigen-positive skeletal muscles, and in one VZV antigen-positive normal TA. Varicella-zoster virions were found in a GCA-positive TA. In sections adjacent to those containing VZV, GCA pathology was seen in 89% of GCA-positive TAs but in none of 18 adjacent sections from normal TAs.
Most GCA-positive TAs contained VZV in skip areas that correlated with adjacent GCA pathology, supporting the hypothesis that VZV triggers GCA immunopathology. Antiviral treatment may confer additional benefit to patients with GCA treated with corticosteroids, although the optimal antiviral regimen remains to be determined.
DescriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the page
RightsArchived with thanks to Neurology
- Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis.
- Authors: Nagel MA, White T, Khmeleva N, Rempel A, Boyer PJ, Bennett JL, Haller A, Lear-Kaul K, Kandasmy B, Amato M, Wood E, Durairaj V, Fogt F, Tamhankar MA, Grossniklaus HE, Poppiti RJ, Bockelman B, Keyvani K, Pollak L, Mendlovic S, Fowkes M, Eberhart CG, Buttmann M, Toyka KV, Meyer-ter-Vehn T, Petursdottir V, Gilden D
- Issue date: 2015 Nov
- Varicella Zoster Virus in Temporal Arteries of Patients With Giant Cell Arteritis.
- Authors: Gilden D, Nagel M
- Issue date: 2015 Jul 15
- Blinded search for varicella zoster virus in giant cell arteritis (GCA)-positive and GCA-negative temporal arteries.
- Authors: Gilden D, White T, Khmeleva N, Katz BJ, Nagel MA
- Issue date: 2016 May 15
- Varicella zoster virus in the temporal artery of a patient with giant cell arteritis.
- Authors: Nagel MA, Khmeleva N, Boyer PJ, Choe A, Bert R, Gilden D
- Issue date: 2013 Dec 15
- No detection of varicella-zoster virus in temporal arteries of patients with giant cell arteritis.
- Authors: Muratore F, Croci S, Tamagnini I, Zerbini A, Bellafiore S, Belloni L, Boiardi L, Bisagni A, Pipitone N, Parmeggiani M, Cavazza A, Salvarani C
- Issue date: 2017 Oct