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dc.contributor.authorGilden, Don
dc.contributor.authorWhite, Teresa
dc.contributor.authorKhmeleva, Nelly
dc.contributor.authorHeintzman, Anna
dc.contributor.authorChoe, Alexander
dc.contributor.authorBoyer, Philip J
dc.contributor.authorGrose, Charles
dc.contributor.authorCarpenter, John E
dc.contributor.authorRempel, April
dc.contributor.authorBos, Nathan
dc.contributor.authorKandasamy, Balasubramaniyam
dc.contributor.authorLear-Kaul, Kelly
dc.contributor.authorHolmes, Dawn B
dc.contributor.authorBennett, Jeffrey L
dc.contributor.authorCohrs, Randall J
dc.contributor.authorMahalingam, Ravi
dc.contributor.authorMandava, Naresh
dc.contributor.authorEberhart, Charles G
dc.contributor.authorBockelman, Brian
dc.contributor.authorPoppiti, Robert J
dc.contributor.authorTamhankar, Madhura A
dc.contributor.authorFogt, Franz
dc.contributor.authorAmato, Malena
dc.contributor.authorWood, Edward
dc.contributor.authorDurairaj, Vikram
dc.contributor.authorRasmussen, Steve
dc.contributor.authorPetursdottir, Vigdis
dc.contributor.authorPollak, Lea
dc.contributor.authorMendlovic, Sonia
dc.contributor.authorChatelain, Denis
dc.contributor.authorKeyvani, Kathy
dc.contributor.authorBrueck, Wolfgang
dc.contributor.authorNagel, Maria A
dc.date.accessioned2015-07-24T14:16:49Zen
dc.date.available2015-07-24T14:16:49Zen
dc.date.issued2015-05-12en
dc.date.submitted2015en
dc.identifier.citationNeurology 2015, 84 (19):1948-55en
dc.identifier.issn1526-632Xen
dc.identifier.pmid25695965en
dc.identifier.doi10.1212/WNL.0000000000001409en
dc.identifier.urihttp://hdl.handle.net/2336/560974en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractVaricella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA).
dc.description.abstractFormalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies (50 sections/TA) including adjacent skeletal muscle and normal TAs obtained postmortem from subjects >50 years of age were examined by immunohistochemistry for presence and distribution of VZV antigen and by ultrastructural examination for virions. Adjacent regions were examined by hematoxylin & eosin staining. VZV antigen-positive slides were analyzed by PCR for VZV DNA.
dc.description.abstractVZV antigen was found in 61/82 (74%) GCA-positive TAs compared with 1/13 (8%) normal TAs (p < 0.0001, relative risk 9.67, 95% confidence interval 1.46, 63.69). Most GCA-positive TAs contained viral antigen in skip areas. VZV antigen was present mostly in adventitia, followed by media and intima. VZV antigen was found in 12/32 (38%) skeletal muscles adjacent to VZV antigen-positive TAs. Despite formalin fixation, VZV DNA was detected in 18/45 (40%) GCA-positive VZV antigen-positive TAs, in 6/10 (60%) VZV antigen-positive skeletal muscles, and in one VZV antigen-positive normal TA. Varicella-zoster virions were found in a GCA-positive TA. In sections adjacent to those containing VZV, GCA pathology was seen in 89% of GCA-positive TAs but in none of 18 adjacent sections from normal TAs.
dc.description.abstractMost GCA-positive TAs contained VZV in skip areas that correlated with adjacent GCA pathology, supporting the hypothesis that VZV triggers GCA immunopathology. Antiviral treatment may confer additional benefit to patients with GCA treated with corticosteroids, although the optimal antiviral regimen remains to be determined.
dc.description.sponsorshipNIH AG032958 NS 067070en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://dx.doi.org/ 10.1212/WNL.0000000000001409en
dc.relation.urlhttp://ovidsp.uk.ovid.com/sp-3.16.0a/ovidweb.cgi?WebLinkFrameset=1&S=LJDLPDFLJLHFNEAGFNKKBGCGGMCEAA00&returnUrl=ovidweb.cgi%3f%26TOC%3djb.search.31%257c1%257c50%26FORMAT%3dtoc%26FIELDS%3dTOC%26S%3dLJDLPDFLJLHFNEAGFNKKBGCGGMCEAA00&directlink=http%3a%2f%2fgraphics.uk.ovid.com%2fovftpdfs%2fPDHFFNCGBGAGJL00%2ffs047%2fovft%2flive%2fgv024%2f00006114%2f00006114-201505120-00009.pdf&filename=Prevalence+and+distribution+of+VZV+in+temporal+arteries+of+patients+with+giant+cell+arteritis.&PDFIdLinkField=%2ffs047%2fovft%2flive%2fgv024%2f00006114%2f00006114-201505120-00009&link_from=jb.search.31%7c1&pdf_key=B&pdf_index=jb.search.31&D=ovften
dc.rightsArchived with thanks to Neurologyen
dc.subjectAldraðiren
dc.subjectHeilablóðfallen
dc.subjectBlóðrásarsjúkdómaren
dc.subjectHlaupabólaen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshCerebral Arterial Diseasesen
dc.subject.meshComorbidityen
dc.subject.meshEncephalitis, Varicella Zosteren
dc.subject.meshFemaleen
dc.subject.meshGiant Cell Arteritisen
dc.subject.meshHerpesvirus 3, Humanen
dc.subject.meshHumansen
dc.subject.meshInternationalityen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPrevalenceen
dc.subject.meshRisk Factorsen
dc.subject.meshTemporal Arteriesen
dc.titlePrevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis.en
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO 80045 USA [ 2 ] Univ Colorado, Sch Med, Dept Microbiol, Aurora, CO USA [ 3 ] Univ Colorado, Sch Med, Dept Pathol, Aurora, CO USA [ 4 ] Univ Colorado, Sch Med, Dept Ophthalmol, Aurora, CO USA [ 5 ] Univ Iowa, Childrens Hosp, Iowa City, IA USA [ 6 ] Arapahoe Cty Coroners Off, Aurora, CO USA [ 7 ] Denver Off Med Examiner, Denver, CO USA [ 8 ] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA [ 9 ] Mt Sinai Med Ctr, AM Rywlin Dept Pathol, Miami Beach, FL 33140 USA [ 10 ] Florida Int Univ, Miami Beach, FL USA [ 11 ] Univ Penn, Scheie Eye Inst, Philadelphia, PA 19104 USA [ 12 ] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA [ 13 ] Texas Oculoplast Consultants, Austin, TX USA [ 14 ] Univ Texas Austin, Southwestern Austin Transit Year Program, Austin, TX 78712 USA [ 15 ] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada [ 16 ] Univ British Columbia, Dept Ophthalmol, Vancouver, BC V5Z 1M9, Canada [ 17 ] Univ British Columbia, Dept Visual Sci, Vancouver, BC V5Z 1M9, Canada [ 18 ] Landspitali Univ Hosp, Reykjavik, Iceland [ 19 ] Tel Aviv Univ, Assaf Harofeh Med Ctr, Dept Neurol, Zerifin, Israel [ 20 ] Tel Aviv Univ, Assaf Harofeh Med Ctr, Inst Pathol, Zerifin, Israel [ 21 ] Ctr Hosp Univ Nord, Dept Pathol, Amiens, France [ 22 ] RECIP, Amiens, France [ 23 ] Univ Duisburg Essen, Inst Neuropathol, Essen, Germany [ 24 ] Univ Med Ctr Gottingen, Dept Neuropathol, Gottingen, Germanyen
dc.identifier.journalNeurologyen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractVaricella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA).
html.description.abstractFormalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies (50 sections/TA) including adjacent skeletal muscle and normal TAs obtained postmortem from subjects >50 years of age were examined by immunohistochemistry for presence and distribution of VZV antigen and by ultrastructural examination for virions. Adjacent regions were examined by hematoxylin & eosin staining. VZV antigen-positive slides were analyzed by PCR for VZV DNA.
html.description.abstractVZV antigen was found in 61/82 (74%) GCA-positive TAs compared with 1/13 (8%) normal TAs (p < 0.0001, relative risk 9.67, 95% confidence interval 1.46, 63.69). Most GCA-positive TAs contained viral antigen in skip areas. VZV antigen was present mostly in adventitia, followed by media and intima. VZV antigen was found in 12/32 (38%) skeletal muscles adjacent to VZV antigen-positive TAs. Despite formalin fixation, VZV DNA was detected in 18/45 (40%) GCA-positive VZV antigen-positive TAs, in 6/10 (60%) VZV antigen-positive skeletal muscles, and in one VZV antigen-positive normal TA. Varicella-zoster virions were found in a GCA-positive TA. In sections adjacent to those containing VZV, GCA pathology was seen in 89% of GCA-positive TAs but in none of 18 adjacent sections from normal TAs.
html.description.abstractMost GCA-positive TAs contained VZV in skip areas that correlated with adjacent GCA pathology, supporting the hypothesis that VZV triggers GCA immunopathology. Antiviral treatment may confer additional benefit to patients with GCA treated with corticosteroids, although the optimal antiviral regimen remains to be determined.


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