Mortality from infections and malignancies in patients treated with renal replacement therapy: data from the ERA-EDTA registry.
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AuthorsVogelzang, Judith L
van Stralen, Karlijn J
Diez, Jose Abad
Carrero, Juan J
Dekker, Friedo W
Heaf, James G
de Meester, Johan
Groothoff, Jaap W
Jager, Kitty J
MetadataShow full item record
CitationNephrol. Dial. Transplant. 2015, 30 (6):1028-37
AbstractInfections and malignancies are the most common non-cardiovascular causes of death in patients on chronic renal replacement therapy (RRT). Here, we aimed to quantify the mortality risk attributed to infections and malignancies in dialysis patients and kidney transplant recipients when compared with the general population by age group and sex.
We followed 168 156 patients included in the ERA-EDTA registry who started RRT in 1993-2007 until 1 January 2012. Age- and cause-specific mortality rates per 1000 person-years (py) and mortality rate ratios (MRRs) compared with the European general population (WHO) were calculated. To identify risk factors, we used Cox regression.
Infection-related mortality was increased 82-fold in dialysis patients and 32-fold in transplant recipients compared with the general population. Female sex, diabetes, cancer and multisystem disease were associated with an increased risk of infection-related mortality. The sex difference was most pronounced for dialysis patients aged 0-39 years, with women having a 32% (adjusted HR 1.32 95% CI 1.09-1.60) higher risk of infection-related mortality than men. Mortality from malignancies was 2.9 times higher in dialysis patients and 1.7 times higher in transplant recipients than in the general population. Cancer and multisystem disease as primary causes of end-stage renal disease were associated with higher mortality from malignancies.
Infection-related mortality is highly increased in dialysis and kidney transplant patients, while the risk of malignancy-related death is moderately increased. Young women on dialysis may deserve special attention because of their high excess risk of infection-related mortality. Further research into the mechanisms, prevention and optimal treatment of infections in this vulnerable population is required.
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RightsArchived with thanks to Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
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- Authors: Hruskova Z, Pippias M, Stel VS, Abad-Díez JM, Benítez Sánchez M, Caskey FJ, Collart F, De Meester J, Finne P, Heaf JG, Magaz A, Palsson R, Reisæter AV, Salama AD, Segelmark M, Traynor JP, Massy ZA, Jager KJ, Tesar V
- Issue date: 2019 Feb
- Trend from cardiovascular to non-cardiovascular late mortality in patients with renal replacement therapy since childhood.
- Authors: Vogelzang JL, van Stralen KJ, Jager KJ, Groothoff JW
- Issue date: 2013 Aug
- Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA-EDTA registry.
- Authors: Chesnaye N, Bonthuis M, Schaefer F, Groothoff JW, Verrina E, Heaf JG, Jankauskiene A, Lukosiene V, Molchanova EA, Mota C, Peco-Antić A, Ratsch IM, Bjerre A, Roussinov DL, Sukalo A, Topaloglu R, Van Hoeck K, Zagozdzon I, Jager KJ, Van Stralen KJ, ESPN/ERA–EDTA registry.
- Issue date: 2014 Dec
- [The Veneto Region's Registry of Dialysis and Transplantation: 2006-2007 report].
- Authors: Antonucci F, Camerin E, Feriani M, Nordio M, Piccoli A, Rossi B, Tessitore N
- Issue date: 2009 Nov-Dec
- Racial Disparities in Access to and Outcomes of Kidney Transplantation in Children, Adolescents, and Young Adults: Results From the ESPN/ERA-EDTA (European Society of Pediatric Nephrology/European Renal Association-European Dialysis and Transplant Association) Registry.
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- Issue date: 2016 Feb