Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.
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Authors
Power, Robert ASteinberg, Stacy
Bjornsdottir, Gyda
Rietveld, Cornelius A
Abdellaoui, Abdel
Nivard, Michel M
Johannesson, Magnus
Galesloot, Tessel E
Hottenga, Jouke J
Willemsen, Gonneke
Cesarini, David
Benjamin, Daniel J
Magnusson, Patrik K E
Ullén, Fredrik
Tiemeier, Henning
Hofman, Albert
van Rooij, Frank J A
Walters, G Bragi
Sigurdsson, Engilbert
Thorgeirsson, Thorgeir E
Ingason, Andres
Helgason, Agnar
Kong, Augustine
Kiemeney, Lambertus A
Koellinger, Philipp
Boomsma, Dorret I
Gudbjartsson, Daniel
Stefansson, Hreinn
Stefansson, Kari
Issue Date
2015-07
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Nat. Neurosci. 2015, 18 (7):953-5Abstract
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.Description
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http://dx.doi.org/ 10.1038/nn.4040Rights
Archived with thanks to Nature neuroscienceae974a485f413a2113503eed53cd6c53
10.1038/nn.4040
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