Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.
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AuthorsPower, Robert A
Rietveld, Cornelius A
Nivard, Michel M
Galesloot, Tessel E
Hottenga, Jouke J
Benjamin, Daniel J
Magnusson, Patrik K E
van Rooij, Frank J A
Walters, G Bragi
Thorgeirsson, Thorgeir E
Kiemeney, Lambertus A
Boomsma, Dorret I
MetadataShow full item record
CitationNat. Neurosci. 2015, 18 (7):953-5
AbstractWe tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
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RightsArchived with thanks to Nature neuroscience
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