Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

Cast your vote
 
Your vote was cast
Thank you for your feedback
Authors
Power, Robert A
Steinberg, Stacy
Bjornsdottir, Gyda
Rietveld, Cornelius A
Abdellaoui, Abdel
Nivard, Michel M
Johannesson, Magnus
Galesloot, Tessel E
Hottenga, Jouke J
Willemsen, Gonneke
Cesarini, David
Benjamin, Daniel J
Magnusson, Patrik K E
Ullén, Fredrik
Tiemeier, Henning
Hofman, Albert
van Rooij, Frank J A
Walters, G Bragi
Sigurdsson, Engilbert
Thorgeirsson, Thorgeir E
Ingason, Andres
Helgason, Agnar
Kong, Augustine
Kiemeney, Lambertus A
Koellinger, Philipp
Boomsma, Dorret I
Gudbjartsson, Daniel
Stefansson, Hreinn
Stefansson, Kari
Issue Date
2015-07

Metadata
Show full item record
Citation
Nat. Neurosci. 2015, 18 (7):953-5
Abstract
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the page
Additional Links
http://dx.doi.org/ 10.1038/nn.4040
Rights
Archived with thanks to Nature neuroscience
Collections