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dc.contributor.authorInker, Lesley A
dc.contributor.authorOkparavero, Aghogho
dc.contributor.authorTighiouart, Hocine
dc.contributor.authorAspelund, Thor
dc.contributor.authorAndresdottir, Margret B
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorHarris, Tamara
dc.contributor.authorLauner, Lenore
dc.contributor.authorNikulasdottir, Hjalmfridur
dc.contributor.authorSverrisdottir, Johanna Eyrun
dc.contributor.authorGudmundsdottir, Hrefna
dc.contributor.authorNoubary, Farzad
dc.contributor.authorMitchell, Gary
dc.contributor.authorPalsson, Runolfur
dc.contributor.authorIndridason, Olafur S
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorLevey, Andrew S
dc.date.accessioned2015-07-30T14:12:25Zen
dc.date.available2015-07-30T14:12:25Zen
dc.date.issued2015-08en
dc.date.submitted2015en
dc.identifier.citationMidlife Blood Pressure and Late-Life GFR and Albuminuria: An Elderly General Population Cohort. 2015, 66 (2):240-8 Am. J. Kidney Dis.en
dc.identifier.issn1523-6838en
dc.identifier.pmid25987258en
dc.identifier.doi10.1053/j.ajkd.2015.03.030en
dc.identifier.urihttp://hdl.handle.net/2336/561276en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractChronic kidney disease (CKD) is common in the elderly, but the cause is often not identifiable. Some posit that age-related reductions in glomerular filtration rate (GFR) and increases in albuminuria are normal, whereas others suggest that they are a consequence of vascular disease.
dc.description.abstractCross-sectional analysis of a substudy of a prospective cohort.
dc.description.abstractAGES (Age, Gene/Environment Susceptibility)-Reykjavik Study.
dc.description.abstractExposure to higher blood pressure in midlife.
dc.description.abstractMeasured GFR using plasma clearance of iohexol and urine albumin-creatinine ratio.
dc.description.abstractGFR was measured in 805 participants with mean age in midlife and late life of 51.0±5.8 and 80.8±4.0 (SD) years, respectively. Mean measured GFR was 62.4±16.5mL/min/1.73m(2) and median albuminuria was 8.0 (IQR, 5.4-16.5) mg/g. Higher midlife systolic and diastolic blood pressures were associated with lower later-life GFRs. Associations persisted after adjustment. Higher midlife systolic and diastolic blood pressures were also associated with higher albumin-creatinine ratios, and associations remained significant even after adjustment.
dc.description.abstractThis is a study of survivors, and people who agreed to participate in this study were healthier than those who refused. Blood pressure may encompass effects of the other risk factors. Results may not be generalizable to populations of other races. We were not able to adjust for measured GFR or albuminuria at the midlife visit.
dc.description.abstractFactors other than advanced age may account for the high prevalence of CKD in the elderly. Midlife factors are potential contributing factors to late-life kidney disease. Further studies are needed to identify and treat midlife modifiable factors to prevent the development of CKD.
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://dx.doi.org/ 10.1053/j.ajkd.2015.03.030en
dc.rightsArchived with thanks to American journal of kidney diseases : the official journal of the National Kidney Foundationen
dc.subjectNýrnabilunen
dc.subjectÖldrunen
dc.subject.meshRenal Insufficiency, Chronicen
dc.subject.meshAgingen
dc.subject.meshAlbuminuriaen
dc.subject.meshBlood Pressureen
dc.subject.meshHypertensionen
dc.subject.meshMiddle Ageden
dc.subject.meshRisk Factorsen
dc.subject.meshDelayed Graft Functionen
dc.titleMidlife Blood Pressure and Late-Life GFR and Albuminuria: An Elderly General Population Cohort.en
dc.typeArticleen
dc.contributor.department1Tufts Medical Center, Boston, MA. Electronic address: linker@tuftsmedicalcenter.org. 2Tufts Medical Center, Boston, MA. 3The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA; Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA. 4Icelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland. 5Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 6Icelandic Heart Association, Kopavogur, Iceland. 7National Institute on Aging, Bethesda, MD. 8Cardiovascular Engineering Inc, Norwood, MA. 9University of Iceland, Reykjavik, Iceland; Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.en
dc.identifier.journalAmerican journal of kidney diseases : the official journal of the National Kidney Foundationen
dc.rights.accessClosed - Lokaðen
html.description.abstractChronic kidney disease (CKD) is common in the elderly, but the cause is often not identifiable. Some posit that age-related reductions in glomerular filtration rate (GFR) and increases in albuminuria are normal, whereas others suggest that they are a consequence of vascular disease.
html.description.abstractCross-sectional analysis of a substudy of a prospective cohort.
html.description.abstractAGES (Age, Gene/Environment Susceptibility)-Reykjavik Study.
html.description.abstractExposure to higher blood pressure in midlife.
html.description.abstractMeasured GFR using plasma clearance of iohexol and urine albumin-creatinine ratio.
html.description.abstractGFR was measured in 805 participants with mean age in midlife and late life of 51.0±5.8 and 80.8±4.0 (SD) years, respectively. Mean measured GFR was 62.4±16.5mL/min/1.73m(2) and median albuminuria was 8.0 (IQR, 5.4-16.5) mg/g. Higher midlife systolic and diastolic blood pressures were associated with lower later-life GFRs. Associations persisted after adjustment. Higher midlife systolic and diastolic blood pressures were also associated with higher albumin-creatinine ratios, and associations remained significant even after adjustment.
html.description.abstractThis is a study of survivors, and people who agreed to participate in this study were healthier than those who refused. Blood pressure may encompass effects of the other risk factors. Results may not be generalizable to populations of other races. We were not able to adjust for measured GFR or albuminuria at the midlife visit.
html.description.abstractFactors other than advanced age may account for the high prevalence of CKD in the elderly. Midlife factors are potential contributing factors to late-life kidney disease. Further studies are needed to identify and treat midlife modifiable factors to prevent the development of CKD.


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