Nocturnal GERD - a risk factor for rhinitis/rhinosinusitis: the RHINE study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationNocturnal GERD - a risk factor for rhinitis/rhinosinusitis: the RHINE study. 2015, 70 (6):697-702 Allergy
AbstractIt has been suggested that gastroesophageal reflux disease (GERD) is a risk factor for developing rhinitis/rhinosinusitis, but data are lacking. This is a prospective 10-year follow-up study of a large multicenter cohort from Northern Europe, evaluating the relationship between nocturnal GERD and noninfectious rhinitis (NIR).
The study comprised 5417 subjects born between 1945 and 1973, who answered a questionnaire in 1999-2001 and again in 2010-2012. Noninfectious rhinitis was defined as having nasal obstruction, secretion, and/or sneezing without having the common cold. Odds ratios for developing NIR in relation to age, gender, BMI, smoking, asthma, and nocturnal GERD were calculated.
During the 10-year observation period, 1034 subjects (19.1%) developed NIR. Subjects reporting nocturnal gastroesophageal reflux in both 1999 and 2010 had more NIR in 2010 (2.8% vs 1.2%, P < 0.001). There was a significant dose-response relationship between the number of reflux episodes/week in 1999 and the risk of having NIR in 2010, P = 0.02. In the multiple regression adjusted for age, gender, BMI, tobacco smoke, and asthma, those with nocturnal GERD in 1999 (≥3 episodes of nocturnal gastroesophageal reflux symptoms per week) had an OR of 1.6 (95% CI 1.0-2.5, P = 0.03) to develop NIR in 2010. Smoking was associated both with an increased risk of developing NIR (30.7% vs 24.0%, P < 0.001) and with the development of nocturnal GERD.
This large, population-based, 10-year study indicates that nocturnal GERD was a risk factor for noninfectious rhinitis/rhinosinusitis. GERD should therefore be considered in patients with rhinitis of known and unknown origin.
DescriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the page
RightsArchived with thanks to Allergy
- New evidence of increased risk of rhinitis in subjects with COPD: a longitudinal population study.
- Authors: Bergqvist J, Andersson A, Olin AC, Murgia N, Schiöler L, Bove M, Hellgren J
- Issue date: 2016
- Increased risk of rhinitis symptoms in subjects with gastroesophageal reflux.
- Authors: Hellgren J, Olin AC, Torén K
- Issue date: 2014 Jun
- Prevalence of allergic rhinitis and asthma in patients with chronic rhinosinusitis and gastroesophageal reflux disease.
- Authors: Mahdavinia M, Bishehsari F, Hayat W, Codispoti CD, Sarrafi S, Husain I, Mehta A, Benhammuda M, Tobin MC, Bandi S, LoSavio PS, Jeffe JS, Palmisano EL, Schleimer RP, Batra PS
- Issue date: 2016 Aug
- Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders.
- Authors: Finocchio E, Locatelli F, Sanna F, Vesentini R, Marchetti P, Spiteri G, Antonicelli L, Battaglia S, Bono R, Corsico AG, Ferrari M, Murgia N, Pirina P, Olivieri M, Verlato G
- Issue date: 2021 Feb 8
- Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case-control study using a national sample cohort.
- Authors: Kim SY, Park B, Lim H, Kim M, Kong IG, Choi HG
- Issue date: 2019 Apr