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dc.contributor.authorBjornsdottir, Erla
dc.contributor.authorKeenan, Brendan T
dc.contributor.authorEysteinsdottir, Bjorg
dc.contributor.authorArnardottir, Erna Sif
dc.contributor.authorJanson, Christer
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorSigurdsson, Jon Fridrik
dc.contributor.authorKuna, Samuel T
dc.contributor.authorPack, Allan I
dc.contributor.authorBenediktsdottir, Bryndis
dc.date.accessioned2015-08-10T14:58:21Zen
dc.date.available2015-08-10T14:58:21Zen
dc.date.issued2015-06en
dc.date.submitted2015en
dc.identifier.citationQuality of life among untreated sleep apnea patients compared with the general population and changes after treatment with positive airway pressure. 2015, 24 (3):328-38 J Sleep Resen
dc.identifier.issn1365-2869en
dc.identifier.pmid25431105en
dc.identifier.doi10.1111/jsr.12262en
dc.identifier.urihttp://hdl.handle.net/2336/565802en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractObstructive sleep apnea leads to recurrent arousals from sleep, oxygen desaturations, daytime sleepiness and fatigue. This can have an adverse impact on quality of life. The aims of this study were to compare: (i) quality of life between the general population and untreated patients with obstructive sleep apnea; and (ii) changes of quality of life among patients with obstructive sleep apnea after 2 years of positive airway pressure treatment between adherent patients and non-users. Propensity score methodologies were used in order to minimize selection bias and strengthen causal inferences. The enrolled obstructive sleep apnea subjects (n = 822) were newly diagnosed with moderate to severe obstructive sleep apnea who were starting positive airway pressure treatment, and the general population subjects (n = 742) were randomly selected Icelanders. The Short Form 12 was used to measure quality of life. Untreated patients with obstructive sleep apnea had a worse quality of life when compared with the general population. This effect remained significant after using propensity scores to select samples, balanced with regard to age, body mass index, gender, smoking, diabetes, hypertension and cardiovascular disease. We did not find significant overall differences between full and non-users of positive airway pressure in improvement of quality of life from baseline to follow-up. However, there was a trend towards more improvement in physical quality of life for positive airway pressure-adherent patients, and the most obese subjects improved their physical quality of life more. The results suggest that co-morbidities of obstructive sleep apnea, such as obesity, insomnia and daytime sleepiness, have a great effect on life qualities and need to be taken into account and addressed with additional interventions.
dc.description.sponsorshipNIH HL72067 HL94307 Eimskip Fund of the University of Iceland Landspitali University Hospital Research Funden
dc.language.isoenen
dc.publisherWiley Online Libraryen
dc.relation.urlhttp://dx.doi.org/ 10.1111/jsr.12262en
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/jsr.12262/epdfen
dc.rightsArchived with thanks to Journal of sleep researchen
dc.subjectSvefnleysien
dc.subjectHroturen
dc.subject.meshSleep Apnea Syndromesen
dc.subject.meshQuality of Lifeen
dc.subject.meshObesityen
dc.subject.meshRehabilitationen
dc.subject.meshContinuous Positive Airway Pressureen
dc.titleQuality of life among untreated sleep apnea patients compared with the general population and changes after treatment with positive airway pressure.en
dc.typeArticleen
dc.contributor.department1Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2Department of Respiratory Medicine and Sleep, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 3Center for Sleep and Circadian Neurobiology, Division of Sleep Medicine/Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 4Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden. 5Mental Health Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 6Reykjavik University, Reykjavik, Iceland. 7Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA.en
dc.identifier.journalJournal of sleep researchen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractObstructive sleep apnea leads to recurrent arousals from sleep, oxygen desaturations, daytime sleepiness and fatigue. This can have an adverse impact on quality of life. The aims of this study were to compare: (i) quality of life between the general population and untreated patients with obstructive sleep apnea; and (ii) changes of quality of life among patients with obstructive sleep apnea after 2 years of positive airway pressure treatment between adherent patients and non-users. Propensity score methodologies were used in order to minimize selection bias and strengthen causal inferences. The enrolled obstructive sleep apnea subjects (n = 822) were newly diagnosed with moderate to severe obstructive sleep apnea who were starting positive airway pressure treatment, and the general population subjects (n = 742) were randomly selected Icelanders. The Short Form 12 was used to measure quality of life. Untreated patients with obstructive sleep apnea had a worse quality of life when compared with the general population. This effect remained significant after using propensity scores to select samples, balanced with regard to age, body mass index, gender, smoking, diabetes, hypertension and cardiovascular disease. We did not find significant overall differences between full and non-users of positive airway pressure in improvement of quality of life from baseline to follow-up. However, there was a trend towards more improvement in physical quality of life for positive airway pressure-adherent patients, and the most obese subjects improved their physical quality of life more. The results suggest that co-morbidities of obstructive sleep apnea, such as obesity, insomnia and daytime sleepiness, have a great effect on life qualities and need to be taken into account and addressed with additional interventions.


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