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dc.contributor.authorKrag, M
dc.contributor.authorPerner, A
dc.contributor.authorWetterslev, J
dc.contributor.authorWise, M P
dc.contributor.authorBorthwick, M
dc.contributor.authorBendel, S
dc.contributor.authorMcArthur, C
dc.contributor.authorCook, D
dc.contributor.authorNielsen, N
dc.contributor.authorPelosi, P
dc.contributor.authorKeus, F
dc.contributor.authorGuttormsen, A B
dc.contributor.authorMoller, A D
dc.contributor.authorMøller, M H
dc.date.accessioned2015-08-12T13:48:28Zen
dc.date.available2015-08-12T13:48:28Zen
dc.date.issued2015-05en
dc.date.submitted2015en
dc.identifier.citationActa Anaesthesiol Scand. 2015, 59 (5):576-85en
dc.identifier.issn1399-6576en
dc.identifier.pmid25880349en
dc.identifier.doi10.1111/aas.12508en
dc.identifier.urihttp://hdl.handle.net/2336/566218en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractStress ulcer prophylaxis (SUP) may decrease the incidence of gastrointestinal bleeding in patients in the intensive care unit (ICU), but the risk of infection may be increased. In this study, we aimed to describe SUP practices in adult ICUs. We hypothesised that patient selection for SUP varies both within and between countries.
dc.description.abstractAdult ICUs were invited to participate in the survey. We registered country, type of hospital, type and size of ICU, preferred SUP agent, presence of local guideline, reported indications for SUP, criteria for discontinuing SUP, and concerns about adverse effects. Fisher's exact test was used to assess differences between groups.
dc.description.abstractNinety-seven adult ICUs in 11 countries participated (eight European). All but one ICU used SUP, and 64% (62/97) reported having a guideline for the use of SUP. Proton pump inhibitors were the most common SUP agent, used in 66% of ICUs (64/97), and H2-receptor antagonists were used 31% (30/97) of the units. Twenty-three different indications for SUP were reported, the most frequent being mechanical ventilation. All patients were prescribed SUP in 26% (25/97) of the ICUs. Adequate enteral feeding was the most frequent reason for discontinuing SUP, but 19% (18/97) continued SUP upon ICU discharge. The majority expressed concern about nosocomial pneumonia and Clostridium difficile infection with the use of SUP.
dc.description.abstractIn this international survey, most participating ICUs reported using SUP, primarily proton pump inhibitors, but many did not have a guideline; indications varied considerably and concern existed about infectious complications.
dc.description.sponsorshipAase and Ejnar Danielsens Foundation Ehrenreichs Foundation Scandinavian Society of Anaesthesia and Intensive Care Medicine (SSAI) Danish Society of Anaesthesiology and Intensive Care Medicine (DASAIM) Danish Medical Associationen
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/ 10.1111/aas.12508en
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aas.12508/epdfen
dc.rightsArchived with thanks to Acta anaesthesiologica Scandinavicaen
dc.subjectGjörgæslaen
dc.subjectMagasáren
dc.subjectStreitaen
dc.subject.meshIntensive Care/methods*en
dc.subject.meshIntensive Care Units*en
dc.subject.meshPeptic Ulcer Hemorrhage/prevention & controlen
dc.subject.meshStress, Physiologicalen
dc.titleStress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries.en
dc.typeArticleen
dc.contributor.department[ 1 ] Rigshosp, Copenhagen Univ Hosp, Dept Intens Care 4131, DK-2100 Copenhagen, Denmark [ 2 ] Rigshosp, Copenhagen Univ Hosp, Ctr Clin Intervent Res, Copenhagen Trial Unit, DK-2100 Copenhagen, Denmark [ 3 ] Univ Wales Hosp, Dept Adult Crit Care, Cardiff CF4 4XW, S Glam, Wales [ 4 ] Oxford Univ Hosp NHS Trust, Dept Pharm, Oxford, England [ 5 ] Kuopio Univ Hosp, Dept Intens Care Med, SF-70210 Kuopio, Finland [ 6 ] Auckland City Hosp, Dept Crit Care Med, Auckland, New Zealand [ 7 ] McMaster Univ, Dept Med, Hamilton, ON, Canada [ 8 ] Helsingborg Hosp, Dept Anaesthesiol & Intens Care, Helsingborg, Sweden [ 9 ] Lund Univ, Dept Clin Sci, Lund, Sweden [ 10 ] Univ Genoa, IRCCS San Martino IST, Dept Surg Sci & Integrated Diagnost, Genoa, Italy [ 11 ] Univ Groningen, Univ Med Ctr Groningen, Dept Crit Care, Groningen, Netherlands [ 12 ] Haukeland Hosp, Dept Anaesthesia & Intens Care, N-5021 Bergen, Norway [ 13 ] Clin Inst 1 UiB, Bergen, Norway [ 14 ] Landspitali Univ Hosp, Dept Anaesthesia & Intens Care, Reykjavik, Icelanden
dc.identifier.journalActa anaesthesiologica Scandinavicaen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractStress ulcer prophylaxis (SUP) may decrease the incidence of gastrointestinal bleeding in patients in the intensive care unit (ICU), but the risk of infection may be increased. In this study, we aimed to describe SUP practices in adult ICUs. We hypothesised that patient selection for SUP varies both within and between countries.
html.description.abstractAdult ICUs were invited to participate in the survey. We registered country, type of hospital, type and size of ICU, preferred SUP agent, presence of local guideline, reported indications for SUP, criteria for discontinuing SUP, and concerns about adverse effects. Fisher's exact test was used to assess differences between groups.
html.description.abstractNinety-seven adult ICUs in 11 countries participated (eight European). All but one ICU used SUP, and 64% (62/97) reported having a guideline for the use of SUP. Proton pump inhibitors were the most common SUP agent, used in 66% of ICUs (64/97), and H2-receptor antagonists were used 31% (30/97) of the units. Twenty-three different indications for SUP were reported, the most frequent being mechanical ventilation. All patients were prescribed SUP in 26% (25/97) of the ICUs. Adequate enteral feeding was the most frequent reason for discontinuing SUP, but 19% (18/97) continued SUP upon ICU discharge. The majority expressed concern about nosocomial pneumonia and Clostridium difficile infection with the use of SUP.
html.description.abstractIn this international survey, most participating ICUs reported using SUP, primarily proton pump inhibitors, but many did not have a guideline; indications varied considerably and concern existed about infectious complications.


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