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dc.contributor.authorSvanes, C
dc.contributor.authorReal, F Gomez
dc.contributor.authorGislason, T
dc.contributor.authorJansson, C
dc.contributor.authorJögi, R
dc.contributor.authorNorrman, E
dc.contributor.authorNyström, L
dc.contributor.authorTorén, K
dc.contributor.authorOmenaas, E
dc.date.accessioned2009-03-27T09:58:55Z
dc.date.available2009-03-27T09:58:55Z
dc.date.issued2005-06-01
dc.date.submitted2009-03-27
dc.identifier.citationThorax. 2005, 60(6):445-50en
dc.identifier.issn0040-6376
dc.identifier.pmid15923242
dc.identifier.doi10.1136/thx.2004.032615
dc.identifier.urihttp://hdl.handle.net/2336/57493
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: There is some evidence that asthmatic women are more likely to have abnormal sex hormone levels. A study was undertaken to determine whether asthma and allergy were associated with irregular menstruation in a general population, and the potential role of asthma medication for this association. METHODS: A total of 8588 women (response rate 77%) participated in an 8 year follow up postal questionnaire study of participants of the ECRHS stage I in Denmark, Estonia, Iceland, Norway, and Sweden. Only non-pregnant women not taking exogenous sex hormones were included in the analyses (n = 6137). RESULTS: Irregular menstruation was associated with asthma (OR 1.54 (95% CI 1.11 to 2.13)), asthma symptoms (OR 1.47 (95% CI 1.16 to 1.86)), hay fever (OR 1.29 (95% CI 1.05 to 1.57)), and asthma preceded by hay fever (OR 1.95 (95% CI 1.30 to 2.96)) among women aged 26-42 years. This was also observed in women not taking asthma medication (asthma symptoms: OR 1.44 (95% CI 1.09 to 1.91); hay fever: OR 1.27 (95% CI 1.03 to 1.58); wheeze preceded by hay fever: OR 1.76 (95% CI 1.18 to 2.64)). Irregular menstruation was associated with new onset asthma in younger women (OR 1.58 (95% CI 1.03 to 2.42)) but not in women aged 42-54 years (OR 0.62 (95% CI 0.32 to 1.18)). The results were consistent across centres. CONCLUSIONS: Younger women with asthma and allergy were more likely to have irregular menstruation. This could not be attributed to current use of asthma medication. The association could possibly be explained by common underlying metabolic or developmental factors. The authors hypothesise that insulin resistance may play a role in asthma and allergy.
dc.language.isoenen
dc.publisherBritish Medical Assnen
dc.relation.urlhttp://thorax.bmj.com/cgi/content/abstract/60/6/445en
dc.subject.meshAdulten
dc.subject.meshAsthmaen
dc.subject.meshEuropeen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshMenstruation Disturbancesen
dc.subject.meshMiddle Ageden
dc.subject.meshOdds Ratioen
dc.subject.meshPrevalenceen
dc.subject.meshQuestionnairesen
dc.subject.meshRegression Analysisen
dc.subject.meshRhinitis, Allergic, Seasonalen
dc.titleAssociation of asthma and hay fever with irregular menstruationen
dc.typeArticleen
dc.contributor.departmentInstitute of Medicine, University of Bergen, Norway. cecilie.svanes@med.uib.noen
dc.identifier.journalThoraxen
html.description.abstractBACKGROUND: There is some evidence that asthmatic women are more likely to have abnormal sex hormone levels. A study was undertaken to determine whether asthma and allergy were associated with irregular menstruation in a general population, and the potential role of asthma medication for this association. METHODS: A total of 8588 women (response rate 77%) participated in an 8 year follow up postal questionnaire study of participants of the ECRHS stage I in Denmark, Estonia, Iceland, Norway, and Sweden. Only non-pregnant women not taking exogenous sex hormones were included in the analyses (n = 6137). RESULTS: Irregular menstruation was associated with asthma (OR 1.54 (95% CI 1.11 to 2.13)), asthma symptoms (OR 1.47 (95% CI 1.16 to 1.86)), hay fever (OR 1.29 (95% CI 1.05 to 1.57)), and asthma preceded by hay fever (OR 1.95 (95% CI 1.30 to 2.96)) among women aged 26-42 years. This was also observed in women not taking asthma medication (asthma symptoms: OR 1.44 (95% CI 1.09 to 1.91); hay fever: OR 1.27 (95% CI 1.03 to 1.58); wheeze preceded by hay fever: OR 1.76 (95% CI 1.18 to 2.64)). Irregular menstruation was associated with new onset asthma in younger women (OR 1.58 (95% CI 1.03 to 2.42)) but not in women aged 42-54 years (OR 0.62 (95% CI 0.32 to 1.18)). The results were consistent across centres. CONCLUSIONS: Younger women with asthma and allergy were more likely to have irregular menstruation. This could not be attributed to current use of asthma medication. The association could possibly be explained by common underlying metabolic or developmental factors. The authors hypothesise that insulin resistance may play a role in asthma and allergy.


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