Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.
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Authors
Sahariah, PriyankaSørensen, Kasper K
Hjálmarsdóttir, Martha Á
Sigurjónsson, Ólafur E
Jensen, Knud J
Másson, Már
Thygesen, Mikkel B
Issue Date
2015-07-25
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Chem. Commun. (Camb.) 2015, 51 (58):11611-4Abstract
Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan.Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageAdditional Links
http://dx.doi.org/ 10.1039/c5cc04010hRights
Archived with thanks to Chemical communications (Cambridge, England)ae974a485f413a2113503eed53cd6c53
10.1039/c5cc04010h
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