Incidence and risk factors for suicide and attempted suicide following a diagnosis of hematological malignancy.
dc.contributor.author | Hultcrantz, Malin | |
dc.contributor.author | Svensson, Tobias | |
dc.contributor.author | Derolf, Åsa R | |
dc.contributor.author | Kristinsson, Sigurdur Y | |
dc.contributor.author | Lindqvist, Ebba K | |
dc.contributor.author | Ekbom, Anders | |
dc.contributor.author | Granath, Fredrik | |
dc.contributor.author | Björkholm, Magnus | |
dc.date.accessioned | 2015-08-18T15:12:51Z | en |
dc.date.available | 2015-08-18T15:12:51Z | en |
dc.date.issued | 2015-01 | en |
dc.date.submitted | 2015 | en |
dc.identifier.citation | Cancer Med. 2015, 4 (1):147-54 | en |
dc.identifier.issn | 2045-7634 | en |
dc.identifier.pmid | 25155101 | en |
dc.identifier.doi | 10.1002/cam4.316 | en |
dc.identifier.uri | http://hdl.handle.net/2336/575148 | en |
dc.description | To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. | en |
dc.description.abstract | Solid tumors are associated with an increased risk of suicide, however, there is limited detailed information on the risk of suicide in patients with hematological malignancies. Therefore, we conducted a population-based study including 47,220 patients with hematological malignancies (diagnosed 1992-2006) and their 235,868 matched controls to define the incidence and risk factors for suicide and suicide attempt. Information on suicides, suicide attempts, and preexisting psychiatric disorders was obtained from Swedish registers and individual medical records. There was a twofold increased (hazard ratio [HR] = 1.9, 95% confidence interval 1.5-2.3, P < 0.0001) risk of suicide/suicide attempt during the first 3 years after diagnosis in patients with hematological malignancies compared to matched controls. Of all hematological malignancies, multiple myeloma was associated with the highest risk (HR = 3.4; 2.3-5.0, P < 0.0001). Patients with a preexisting psychiatric disorder were at a very high risk of suicide and suicide attempt (HR = 23.3; 16.6-32.6, P < 0.0001), regardless of type of hematological malignancy. Among patients who committed suicide, 19% were in a palliative phase and 44% were in remission with no active treatment. In conclusion, the risk of suicide and suicide attempt is elevated in patients with hematological malignancies. Certain high-risk patients may benefit from early detection and preventive measures. | |
dc.description.sponsorship | Swedish Cancer Society CAN 2012/483 regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet 20120004 Adolf H Lundin Charitable Foundation Blodcancerfonden | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.relation.url | http://dx.doi.org/ 10.1002/cam4.316 | en |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312128/ | en |
dc.rights | Archived with thanks to Cancer medicine | en |
dc.subject | Krabbamein | en |
dc.subject | Sjálfsvíg | en |
dc.subject | Geðsjúkdómar | en |
dc.subject.mesh | Retrospective Studies | en |
dc.subject.mesh | Risk Factors | en |
dc.subject.mesh | Suicide, Attempted/statistics & numerical data* | en |
dc.subject.mesh | Iceland/epidemiology Young Adu | en |
dc.subject.mesh | Hematologic Neoplasms | en |
dc.subject.mesh | Multiple Myeloma | en |
dc.subject.mesh | Mental Disorders | en |
dc.subject.mesh | Suicide | en |
dc.title | Incidence and risk factors for suicide and attempted suicide following a diagnosis of hematological malignancy. | en |
dc.type | Article | en |
dc.contributor.department | [ 1 ] Karolinska Univ Hosp Solna, Div Hematol, Dept Med, SE-17176 Stockholm, Sweden [ 2 ] Karolinska Inst, Stockholm, Sweden [ 3 ] Karolinska Univ Hosp Solna, Clin Epidemiol Unit, Dept Med, SE-17176 Stockholm, Sweden [ 4 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 5 ] Landspitali Natl Univ Hosp, Dept Hematol, Reykjavik, Iceland | en |
dc.identifier.journal | Cancer medicine | en |
dc.rights.access | Open Access | en |
html.description.abstract | Solid tumors are associated with an increased risk of suicide, however, there is limited detailed information on the risk of suicide in patients with hematological malignancies. Therefore, we conducted a population-based study including 47,220 patients with hematological malignancies (diagnosed 1992-2006) and their 235,868 matched controls to define the incidence and risk factors for suicide and suicide attempt. Information on suicides, suicide attempts, and preexisting psychiatric disorders was obtained from Swedish registers and individual medical records. There was a twofold increased (hazard ratio [HR] = 1.9, 95% confidence interval 1.5-2.3, P < 0.0001) risk of suicide/suicide attempt during the first 3 years after diagnosis in patients with hematological malignancies compared to matched controls. Of all hematological malignancies, multiple myeloma was associated with the highest risk (HR = 3.4; 2.3-5.0, P < 0.0001). Patients with a preexisting psychiatric disorder were at a very high risk of suicide and suicide attempt (HR = 23.3; 16.6-32.6, P < 0.0001), regardless of type of hematological malignancy. Among patients who committed suicide, 19% were in a palliative phase and 44% were in remission with no active treatment. In conclusion, the risk of suicide and suicide attempt is elevated in patients with hematological malignancies. Certain high-risk patients may benefit from early detection and preventive measures. |