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dc.contributor.authorFan, Li
dc.contributor.authorLevey, Andrew S
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorAndresdottir, Margret B
dc.contributor.authorGudmundsdottir, Hrefna
dc.contributor.authorIndridason, Olafur S
dc.contributor.authorPalsson, Runolfur
dc.contributor.authorMitchell, Gary
dc.contributor.authorInker, Lesley A
dc.date.accessioned2015-09-10T14:32:34Zen
dc.date.available2015-09-10T14:32:34Zen
dc.date.issued2015-08en
dc.date.submitted2015en
dc.identifier.citationJ. Am. Soc. Nephrol. 2015, 26 (8):1982-9en
dc.identifier.issn1533-3450en
dc.identifier.pmid25527647en
dc.identifier.doi10.1681/ASN.2014060607en
dc.identifier.urihttp://hdl.handle.net/2336/577145en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractCurrent guidelines recommend reporting eGFR using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations unless other equations are more accurate, and recommend the combination of creatinine and cystatin C (eGFRcr-cys) as more accurate than either eGFRcr or eGFRcys alone. However, preferred equations and filtration markers in elderly individuals are debated. In 805 adults enrolled in the community-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we measured GFR (mGFR) using plasma clearance of iohexol, standardized creatinine and cystatin C, and eGFR using the CKD-EPI, Japanese, Berlin Initiative Study (BIS), and Caucasian and Asian pediatric and adult subjects (CAPA) equations. We evaluated equation performance using bias, precision, and two measures of accuracy. We first compared the Japanese, BIS, and CAPA equations with the CKD-EPI equations to determine the preferred equations, and then compared eGFRcr and eGFRcys with eGFRcr-cys using the preferred equations. Mean (SD) age was 80.3 (4.0) years. Median (25th, 75th) mGFR was 64 (52, 73) ml/min per 1.73 m(2), and the prevalence of decreased GFR was 39% (95% confidence interval, 35.8 to 42.5). Among 24 comparisons with the other equations, CKD-EPI equations performed better in 9, similar in 13, and worse in 2. Using the CKD-EPI equations, eGFRcr-cys performed better than eGFRcr in four metrics, better than eGFRcys in two metrics, and similar to eGFRcys in two metrics. In conclusion, neither the Japanese, BIS, nor CAPA equations were superior to the CKD-EPI equations in this cohort of community-dwelling elderly individuals. Using the CKD-EPI equations, eGFRcr-cys performed better than eGFRcr or eGFRcys.
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases R01-DK082447 01A1S1en
dc.language.isoenen
dc.publisherAmer Soc Nephrologyen
dc.relation.urlhttp://dx.doi.org/ 10.1681/ASN.2014060607en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001724/en
dc.rightsArchived with thanks to Journal of the American Society of Nephrology : JASNen
dc.subjectNýrnasjúkdómaren
dc.subjectAldraðiren
dc.subject.meshRenal Insufficiency, Chronicen
dc.subject.meshCreatinineen
dc.subject.meshCystatin Cen
dc.subject.meshAgeden
dc.subject.meshGlomerular Filtration Rateen
dc.titleComparing GFR Estimating Equations Using Cystatin C and Creatinine in Elderly Individuals.en
dc.typeArticleen
dc.contributor.department[ 1 ] Tufts Med Ctr, Div Nephrol, Boston, MA 02111 USA [ 2 ] Sun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 1, Key Lab Nephrol,Minist Hlth China,Guangdong Prov, Guangzhou 510275, Guangdong, Peoples R China [ 3 ] Iceland Heart Assoc, Kopavogur, Iceland [ 4 ] Univ Iceland, Ctr Publ Hlth Sci, Reykjavik, Iceland [ 5 ] Landspitali, Div Nephrol, Reykjavik, Iceland [ 6 ] Cardiovasc Engn Inc, Norwood, MA USAen
dc.identifier.journalJournal of the American Society of Nephrology : JASNen
dc.rights.accessOpen Access - Opinn aðganguren
html.description.abstractCurrent guidelines recommend reporting eGFR using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations unless other equations are more accurate, and recommend the combination of creatinine and cystatin C (eGFRcr-cys) as more accurate than either eGFRcr or eGFRcys alone. However, preferred equations and filtration markers in elderly individuals are debated. In 805 adults enrolled in the community-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we measured GFR (mGFR) using plasma clearance of iohexol, standardized creatinine and cystatin C, and eGFR using the CKD-EPI, Japanese, Berlin Initiative Study (BIS), and Caucasian and Asian pediatric and adult subjects (CAPA) equations. We evaluated equation performance using bias, precision, and two measures of accuracy. We first compared the Japanese, BIS, and CAPA equations with the CKD-EPI equations to determine the preferred equations, and then compared eGFRcr and eGFRcys with eGFRcr-cys using the preferred equations. Mean (SD) age was 80.3 (4.0) years. Median (25th, 75th) mGFR was 64 (52, 73) ml/min per 1.73 m(2), and the prevalence of decreased GFR was 39% (95% confidence interval, 35.8 to 42.5). Among 24 comparisons with the other equations, CKD-EPI equations performed better in 9, similar in 13, and worse in 2. Using the CKD-EPI equations, eGFRcr-cys performed better than eGFRcr in four metrics, better than eGFRcys in two metrics, and similar to eGFRcys in two metrics. In conclusion, neither the Japanese, BIS, nor CAPA equations were superior to the CKD-EPI equations in this cohort of community-dwelling elderly individuals. Using the CKD-EPI equations, eGFRcr-cys performed better than eGFRcr or eGFRcys.


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