Drug-induced liver injury: an overview over the most critical compounds.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Björnsson, Einar SÚtgáfudagur
2015-03
Metadata
Show full item recordCitation
Arch. Toxicol. 2015, 89 (3):327-34Útdráttur
There has been a substantial interest in drug-induced liver injury (DILI) recently. National Institutes of Health has sponsored a multicenter study in the USA for the last 10 years, which has collected valuable information in this context. Idiosyncratic DILI is like other adverse effects of drugs underestimated and underreported in most epidemiological studies. A recent prospective population-based study from Iceland found a crude incidence of approximately 19 cases per 100,000 and year. Antibiotic is the class of drugs most commonly implicated in patients with DILI. Amoxicillin-clavulanate continues to be the most commonly implicated agent occurring in approximately 1 out of 2,300 users. Drugs with the highest risk of DILI in the Icelandic study were azathioprine and infliximab. Although rare, statin-induced hepatotoxicity has been well documented. Liver injury associated with the use of herbal medicines and dietary supplements seems to be increasing. Information on the documented hepatotoxicity of drugs has recently been made easier by a website available in the public domain: LiverTox ( http://livertox.nlm.nih.gov ). Unfortunately, at the current time, pre-therapy risk assessment for DILI in the individual patient is difficult but previous well-documented hepatotoxicity is usually a contraindication for a subsequent treatment with the same drug.Lu00FDsing
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageVefslóð
http://dx.doi.org/ 10.1007/s00204-015-1456-2http://download.springer.com/static/pdf/619/art%253A10.1007%252Fs00204-015-1456-2.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00204-015-1456-2&token2=exp=1441983058~acl=%2Fstatic%2Fpdf%2F619%2Fart%25253A10.1007%25252Fs00204-015-1456-2.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs00204-015-1456-2*~hmac=4d204891d6c0249bcd4a73826b91aaddad29c219cc59354ba78b3069473798cc
Rights
Archived with thanks to Archives of toxicologyae974a485f413a2113503eed53cd6c53
10.1007/s00204-015-1456-2
Scopus Count
Collections
Related articles
- Hepatotoxicity by Drugs: The Most Common Implicated Agents.
- Authors: Björnsson ES
- Issue date: 2016 Feb 6
- Epidemiology and risk factors for idiosyncratic drug-induced liver injury.
- Authors: Björnsson ES
- Issue date: 2014 May
- Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland.
- Authors: Björnsson ES, Bergmann OM, Björnsson HK, Kvaran RB, Olafsson S
- Issue date: 2013 Jun
- Adverse drug reactions and organ damage: The liver.
- Authors: Licata A
- Issue date: 2016 Mar
- An update on drug induced liver injury.
- Authors: Rangnekar AS, Fontana RJ
- Issue date: 2011 Jun