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dc.contributor.authorRubio, Carlos A
dc.contributor.authorJónasson, Jón G
dc.date.accessioned2015-09-23T13:04:52Zen
dc.date.available2015-09-23T13:04:52Zen
dc.date.issued2015-09en
dc.date.submitted2015en
dc.identifier.citationAnticancer Res. 2015, 35 (9):4929-33en
dc.identifier.issn1791-7530en
dc.identifier.pmid26254390en
dc.identifier.urihttp://hdl.handle.net/2336/578654en
dc.description.abstractIceland has a total population of 300,000 inhabitants. All patients consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all polyps were endoscopically removed. Out of the total 3,037 colorectal adenomas (CRAs), 308 (10.2%) were traditional serrated adenomas (TSAs). TSAs were divided according the predominant histological phenotype (>50%) into those with ectopic crypt formations (ECF), and those with unlocked serrations (US). ECF-TSA accounted for 5.9% (178/3037) and US-TSA for 4.3% (130/3037). The majority of patients with ECF-TSA and US-TSA were ≥60 years of age (74.1% and 76.2%, respectively). Notwithstanding, when patients having advanced adenomas (with high-grade dysplasia, with or without intramucosal carcinoma) were listed by age, those with ECF-TSA were significantly younger than those with US-TSA (p<0.05). ECF-TSA were more frequently left-sided (71.8%), whereas US-TSA were more frequently right-sided (60.0%). Invasive carcinoma evolved more frequently in ECF-TSA (7.8%) and in US-TSA (7.7%) than in tubular adenomas and in villous/tubulovillous adenonas (0.1% and 4.4%, respectively). Comparative studies indicated that the incidence rates/year of ECF-TSA and US-TSA were significantly higher in Iceland than in Sweden or in Italy (p<0.05). Genetic and putative epigenetic (environmental) factor(s) might account for the high incidence rate/year of ECF-TSA and US-TSA in this country.
dc.description.sponsorshipKarolinska University Hospital, Stockholm. Swedenen
dc.language.isoenen
dc.publisherInt Inst Anticancer Researchen
dc.rightsArchived with thanks to Anticancer researchen
dc.subjectRistilkrabbameinen
dc.subject.meshAdenoma/epidemiologyen
dc.subject.meshAdenoma/pathologyen
dc.subject.meshIncidenceen
dc.subject.meshIcelanden
dc.subject.meshCarcinomaen
dc.subject.meshColorectal Neoplasmsen
dc.subject.meshColonic Polypsen
dc.titleTwo Phenotypes of Traditional Serrated Adenomas Nationwide Survey in Iceland.en
dc.typeArticleen
dc.contributor.department[ 1 ] Karolinska Inst, Dept Pathol, S-17176 Stockholm, Sweden [ 2 ] Univ Hosp, S-17176 Stockholm, Sweden [ 3 ] Univ Hosp, Dept Pathol, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospitalen
dc.identifier.journalAnticancer researchen
dc.rights.accessClosed - Lokaðen
html.description.abstractIceland has a total population of 300,000 inhabitants. All patients consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all polyps were endoscopically removed. Out of the total 3,037 colorectal adenomas (CRAs), 308 (10.2%) were traditional serrated adenomas (TSAs). TSAs were divided according the predominant histological phenotype (>50%) into those with ectopic crypt formations (ECF), and those with unlocked serrations (US). ECF-TSA accounted for 5.9% (178/3037) and US-TSA for 4.3% (130/3037). The majority of patients with ECF-TSA and US-TSA were ≥60 years of age (74.1% and 76.2%, respectively). Notwithstanding, when patients having advanced adenomas (with high-grade dysplasia, with or without intramucosal carcinoma) were listed by age, those with ECF-TSA were significantly younger than those with US-TSA (p<0.05). ECF-TSA were more frequently left-sided (71.8%), whereas US-TSA were more frequently right-sided (60.0%). Invasive carcinoma evolved more frequently in ECF-TSA (7.8%) and in US-TSA (7.7%) than in tubular adenomas and in villous/tubulovillous adenonas (0.1% and 4.4%, respectively). Comparative studies indicated that the incidence rates/year of ECF-TSA and US-TSA were significantly higher in Iceland than in Sweden or in Italy (p<0.05). Genetic and putative epigenetic (environmental) factor(s) might account for the high incidence rate/year of ECF-TSA and US-TSA in this country.


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