• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

GABA agonists fail to protect the retina from ischemia-reperfusion injury

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Thumbnail
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Traustason, Sindri
Eysteinsson, Thor
Agnarsson, Bjarni A
Stefansson, Einar
Issue Date
2009-03-01

Metadata
Show full item record
Citation
Exp. Eye Res. 2009, 88(3):361-6
Abstract
The purpose of this study was to test the hypothesis that ischemia/reperfusion injury in the rat retina may be ameliorated by reducing retinal metabolism with either hypothermia or inhibitory GABA agonists. The intraocular pressure of each right eye in rats was raised to 130 mm Hg for 60 min with the left eye serving as normal control. The rats were divided into four groups in terms of drug and hypothermia treatment: (1) Untreated ischemia, (2) Hypothermia, (3) Baclofen/midazolam and (4) Baclofen/muscimol. Electroretinogram was recorded before ischemia and again after 10-day reperfusion. Histological analysis with H&E staining and cell counts was performed. Untreated ischemia/reperfusion resulted in severely reduced ERG responses. The ERG b-wave was reduced from 423+/-144 microV to 130+/-91 microV (mean+/-SD, n=5). With hypothermia the ERG b-wave was reduced from 499+/-80 microV to 237+/-111 microV (n=4). With combinations of baclofen and midazolam the ERG b-wave was reduced from 432+/-96 microV to 104+/-67 microV (n=7). In baclofen/muscimol treated eyes the ERG b-wave went from 426+/-101 microV to 148+/-118 microV (n=6). The histological tissue damage was severe in untreated ischemia and the baclofen/midazolam and baclofen/muscimol groups, but less severe in the hypothermia group. The GABA agonists do not provide any protection in our ischemia/reperfusion model. Our results are consistent with earlier reports that hypothermia may be helpful in ischemic conditions in the retina.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links
http://www.sciencedirect.com/science/article/B6WFD-4V42JBN-2/2/b850bc0d895e5e351dbe894e1282a4a0
ae974a485f413a2113503eed53cd6c53
10.1016/j.exer.2008.07.019
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Protective effect of adult T-cell leukemia-derived factor on retinal ischemia-reperfusion injury in the rat.
  • Authors: Shibuki H, Katai N, Kuroiwa S, Kurokawa T, Yodoi J, Yoshimura N
  • Issue date: 1998 Jul
  • Protection of rabbit retina from ischemic injury by flupirtine.
  • Authors: Osborne NN, Schwarz M, Pergande G
  • Issue date: 1996 Feb
  • Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
  • Authors: Xu J, Li C, Yin XH, Zhang GY
  • Issue date: 2008 Jun
  • Involvement of adenosine in retinal ischemia. Studies on the rat.
  • Authors: Larsen AK, Osborne NN
  • Issue date: 1996 Dec
  • Opioid receptor-activation: retina protected from ischemic injury.
  • Authors: Husain S, Potter DE, Crosson CE
  • Issue date: 2009 Aug

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.