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dc.contributor.authorSpencer, Benjamin W J
dc.contributor.authorPrainsack, Barbara
dc.contributor.authorRujescu, Dan
dc.contributor.authorGiegling, Ina
dc.contributor.authorCollier, David A
dc.contributor.authorGaughran, Fiona
dc.contributor.authorMacCabe, James H
dc.contributor.authorBarr, Cathy L
dc.contributor.authorSigurdsson, Engilbert
dc.contributor.authorStovring, Henrik
dc.contributor.authorMalhotra, Anil K
dc.contributor.authorCurran, Sarah R
dc.date.accessioned2016-03-10T15:45:14Zen
dc.date.available2016-03-10T15:45:14Zen
dc.date.issued2013-11en
dc.date.submitted2016en
dc.identifier.citationPharmacogenomics 2013, 14 (15):1907-14en
dc.identifier.issn1744-8042en
dc.identifier.pmid24236489en
dc.identifier.doi10.2217/pgs.13.182en
dc.identifier.urihttp://hdl.handle.net/2336/601131en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractClozapine is a uniquely efficacious antipsychotic drug in treatment-resistant schizophrenia. Its use is restricted due to adverse effects including a rare but dangerous reduction in neutrophils (agranulocytosis) and the mandatory hematological monitoring this entails in many countries. We review the statistical, ethical and legal issues arising from a hypothetical pharmacogenetic test for clozapine, using the UK as an exemplary case for consideration. Our key findings include: a consideration of the probabilistic results that a pharmacogenetic test may return; the impact on drug licensing; and the potential for pharmacogenetic tests for clozapine being used without consent under the UK's legal framework. We make recommendations regarding regulatory changes applicable to the special case of pharmacogenetic testing in clozapine treatment.
dc.description.sponsorshipNational Institute for Health Research info:eu-repo/grantAgreement/EC/FP7/279227en
dc.language.isoenen
dc.publisherFUTURE MEDICINE LTDen
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/279227en
dc.relation.urlhttp://dx.doi.org/10.2217/pgs.13.182en
dc.rightsclosedAccessen
dc.subjectGeðklofien
dc.subjectLyfen
dc.subject.meshAntipsychotic Agentsen
dc.subject.meshClozapineen
dc.subject.meshDrug-Related Side Effects and Adverse Reactionsen
dc.subject.meshGreat Britainen
dc.subject.meshHumansen
dc.subject.meshPharmacogeneticsen
dc.subject.meshSchizophreniaen
dc.titleOpening Pandora's box in the UK: a hypothetical pharmacogenetic test for clozapine.en
dc.typearticleen
dc.contributor.department[ 1 ] South London & Maudsley NHS Fdn Trust, London, England [ 2 ] Kings Coll London, Inst Psychiat, London, England [ 3 ] Kings Coll London, Dept Social Sci Hlth & Med, London, England [ 4 ] Univ Halle, Dept Psychiat, Halle, Germany [ 5 ] Toronto Western Res Inst, Toronto, ON, Canada [ 6 ] Hosp Sick Children, Toronto, ON M5G 1X8, Canada [ 7 ] Univ Iceland, Reykjavik, Iceland [ 8 ] Landspitali Univ Hosp, Dept Psychiat, Reykjavik, Iceland [ 9 ] Aarhus Univ, Dept Publ Hlth, DK-8000 Aarhus C, Denmark [ 10 ] Zucker Hillside Hosp, Glen Oaks, NY USA [ 11 ] Hofstra North Shore LIJ Sch Med, Hemptead, NY USAen
dc.identifier.journalPharmacogenomicsen
dc.rights.accessClosed - Lokaðen
html.description.abstractClozapine is a uniquely efficacious antipsychotic drug in treatment-resistant schizophrenia. Its use is restricted due to adverse effects including a rare but dangerous reduction in neutrophils (agranulocytosis) and the mandatory hematological monitoring this entails in many countries. We review the statistical, ethical and legal issues arising from a hypothetical pharmacogenetic test for clozapine, using the UK as an exemplary case for consideration. Our key findings include: a consideration of the probabilistic results that a pharmacogenetic test may return; the impact on drug licensing; and the potential for pharmacogenetic tests for clozapine being used without consent under the UK's legal framework. We make recommendations regarding regulatory changes applicable to the special case of pharmacogenetic testing in clozapine treatment.


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