• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Gottlieb, D J
Hek, K
Chen, T-H
Watson, N F
Eiriksdottir, G
Byrne, E M
Cornelis, M
Warby, S C
Bandinelli, S
Cherkas, L
Evans, D S
Grabe, H J
Lahti, J
Li, M
Lehtimäki, T
Lumley, T
Marciante, K D
Pérusse, L
Psaty, B M
Robbins, J
Tranah, G J
Vink, J M
Wilk, J B
Stafford, J M
Bellis, C
Biffar, R
Bouchard, C
Cade, B
Curhan, G C
Eriksson, J G
Ewert, R
Ferrucci, L
Fülöp, T
Gehrman, P R
Goodloe, R
Harris, T B
Heath, A C
Hernandez, D
Hofman, A
Hottenga, J-J
Hunter, D J
Jensen, M K
Johnson, A D
Kähönen, M
Kao, L
Kraft, P
Larkin, E K
Lauderdale, D S
Luik, A I
Medici, M
Montgomery, G W
Palotie, A
Patel, S R
Pistis, G
Porcu, E
Quaye, L
Raitakari, O
Redline, S
Rimm, E B
Rotter, J I
Smith, A V
Spector, T D
Teumer, A
Uitterlinden, A G
Vohl, M-C
Widen, E
Willemsen, G
Young, T
Zhang, X
Liu, Y
Blangero, J
Boomsma, D I
Gudnason, V
Hu, F
Mangino, M
Martin, N G
O'Connor, G T
Stone, K L
Tanaka, T
Viikari, J
Gharib, S A
Punjabi, N M
Räikkönen, K
Völzke, H
Mignot, E
Tiemeier, H
Show allShow less
Issue Date
2015-10

Metadata
Show full item record
Citation
Mol. Psychiatry 2015, 20 (10):1232-9
Abstract
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the page
Additional Links
http://dx.doi.org/10.1038/mp.2014.133
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430294/
http://www.nature.com/mp/journal/v20/n10/pdf/mp2014133a.pdf
Rights
Archived with thanks to Molecular psychiatry
ae974a485f413a2113503eed53cd6c53
10.1038/mp.2014.133
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population.
  • Authors: Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S
  • Issue date: 2019 Jun 11
  • Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans.
  • Authors: Evans DS, Avery CL, Nalls MA, Li G, Barnard J, Smith EN, Tanaka T, Butler AM, Buxbaum SG, Alonso A, Arking DE, Berenson GS, Bis JC, Buyske S, Carty CL, Chen W, Chung MK, Cummings SR, Deo R, Eaton CB, Fox ER, Heckbert SR, Heiss G, Hindorff LA, Hsueh WC, Isaacs A, Jamshidi Y, Kerr KF, Liu F, Liu Y, Lohman KK, Magnani JW, Maher JF, Mehra R, Meng YA, Musani SK, Newton-Cheh C, North KE, Psaty BM, Redline S, Rotter JI, Schnabel RB, Schork NJ, Shohet RV, Singleton AB, Smith JD, Soliman EZ, Srinivasan SR, Taylor HA Jr, Van Wagoner DR, Wilson JG, Young T, Zhang ZM, Zonderman AB, Evans MK, Ferrucci L, Murray SS, Tranah GJ, Whitsel EA, Reiner AP, CHARGE QRS Consortium., Sotoodehnia N
  • Issue date: 2016 Oct 1
  • Genome-wide association study of sleep duration in the Finnish population.
  • Authors: Ollila HM, Kettunen J, Pietiläinen O, Aho V, Silander K, Kronholm E, Perola M, Lahti J, Räikkönen K, Widen E, Palotie A, Eriksson JG, Partonen T, Kaprio J, Salomaa V, Raitakari O, Lehtimäki T, Sallinen M, Härmä M, Porkka-Heiskanen T, Paunio T
  • Issue date: 2014 Dec
  • Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
  • Authors: Hancock DB, Guo Y, Reginsson GW, Gaddis NC, Lutz SM, Sherva R, Loukola A, Minica CC, Markunas CA, Han Y, Young KA, Gudbjartsson DF, Gu F, McNeil DW, Qaiser B, Glasheen C, Olson S, Landi MT, Madden PAF, Farrer LA, Vink J, Saccone NL, Neale MC, Kranzler HR, McKay J, Hung RJ, Amos CI, Marazita ML, Boomsma DI, Baker TB, Gelernter J, Kaprio J, Caporaso NE, Thorgeirsson TE, Hokanson JE, Bierut LJ, Stefansson K, Johnson EO
  • Issue date: 2018 Sep
  • Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
  • Authors: Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA
  • Issue date: 2015 Mar 1

DSpace software (copyright © 2002 - 2022)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.