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dc.contributor.authorOrmarsson, Orri Thor
dc.contributor.authorAsgrimsdottir, Gudrun Marta
dc.contributor.authorLoftsson, Thorsteinn
dc.contributor.authorStefansson, Einar
dc.contributor.authorKristinsson, Jon Orvar
dc.contributor.authorLund, Sigrun Helga
dc.contributor.authorBjornsson, Einar Stefan
dc.date.accessioned2016-04-14T10:56:53Zen
dc.date.available2016-04-14T10:56:53Zen
dc.date.issued2015-10en
dc.date.submitted2016en
dc.identifier.citationFrontline Gastroenterol. 2015, 6 (4):278-283en
dc.identifier.issn2041-4137en
dc.identifier.pmid26500756en
dc.identifier.doi10.1136/flgastro-2014-100497en
dc.identifier.urihttp://hdl.handle.net/2336/605246en
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractThe purpose of this trial was to evaluate the efficacy and safety of recently developed suppositories containing free fatty acids as a bowel-cleansing agent prior to flexible sigmoidoscopy and compare them with Klyx (docusate sodium/sorbitol).
dc.description.abstractA controlled, non-inferiority, single-blind, randomised study on outpatients undergoing flexible sigmoidoscopy.
dc.description.abstractDepartment of Gastroenterology, Landspitali-University Hospital and endoscopic clinic.
dc.description.abstract53 outpatients undergoing flexible sigmoidoscopy.
dc.description.abstractParticipants were randomised to receive either free fatty acid suppositories (28) or a standard bowel preparation with Klyx enema (25). In the study group, two suppositories were administered the evening before as well as 2 h prior to the sigmoidoscopy. In the control group, Klyx enema (120 mL) was administered the evening before and repeated 2 h prior to the procedure.
dc.description.abstractQuality of the bowel cleansing, height of scope insertion and safety.
dc.description.abstractThe mean height of scope insertion and bowel cleansing was 43 cm (SD=13.4) in the study group and 48 cm (SD=10.4) in the control group (NS). The investigating physicians were less satisfied with the bowel preparation in the study group compared with the control group with a difference of 20% (p<0.016). The amount of faeces noted in the rectum was similar in both groups with no significant difference (p<0.56). No serious side effects, toxic reaction or irritation were observed.
dc.description.abstractThe suppositories are well tolerated with no significant side effects. The suppositories had distinct bowel emptying effect and as effective as Klyx in rectal cleansing. Although physician's satisfaction was slightly lower, the height of scope insertion was similar.
dc.description.abstractEudraCT nr.: 2010-018761-35.
dc.languageENGen
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1136/flgastro-2014-100497en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602256/en
dc.rightsArchived with thanks to Frontline gastroenterologyen
dc.subjectRistilspeglunen
dc.subject.meshColonoscopyen
dc.subject.meshEndoscopyen
dc.subject.meshLipidsen
dc.subject.meshFatty Acids, Nonesterifieden
dc.titleClinical trial: free fatty acid suppositories compared with enema as bowel preparation for flexible sigmoidoscopy.en
dc.typeArticleen
dc.contributor.department1Department of Paediatric Surgery , Landspitali-University Hospital , Reykjavík , Iceland. 2Lipid Pharmaceuticals , Reykjavik , Iceland. 3Department of Pharmacy , University of Iceland , Reykjavik , Iceland. 4Department of Ophtalmology , Landspitali-University Hospital , Reykjavík , Iceland. 5Department of Gastroenterology , Landspitali-University Hospital , Reykjavík , Iceland. 6Department of Public Health , University of Iceland , Reykjavik , Iceland.en
dc.identifier.journalFrontline gastroenterologyen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T15:53:33Z
html.description.abstractThe purpose of this trial was to evaluate the efficacy and safety of recently developed suppositories containing free fatty acids as a bowel-cleansing agent prior to flexible sigmoidoscopy and compare them with Klyx (docusate sodium/sorbitol).
html.description.abstractA controlled, non-inferiority, single-blind, randomised study on outpatients undergoing flexible sigmoidoscopy.
html.description.abstractDepartment of Gastroenterology, Landspitali-University Hospital and endoscopic clinic.
html.description.abstract53 outpatients undergoing flexible sigmoidoscopy.
html.description.abstractParticipants were randomised to receive either free fatty acid suppositories (28) or a standard bowel preparation with Klyx enema (25). In the study group, two suppositories were administered the evening before as well as 2 h prior to the sigmoidoscopy. In the control group, Klyx enema (120 mL) was administered the evening before and repeated 2 h prior to the procedure.
html.description.abstractQuality of the bowel cleansing, height of scope insertion and safety.
html.description.abstractThe mean height of scope insertion and bowel cleansing was 43 cm (SD=13.4) in the study group and 48 cm (SD=10.4) in the control group (NS). The investigating physicians were less satisfied with the bowel preparation in the study group compared with the control group with a difference of 20% (p<0.016). The amount of faeces noted in the rectum was similar in both groups with no significant difference (p<0.56). No serious side effects, toxic reaction or irritation were observed.
html.description.abstractThe suppositories are well tolerated with no significant side effects. The suppositories had distinct bowel emptying effect and as effective as Klyx in rectal cleansing. Although physician's satisfaction was slightly lower, the height of scope insertion was similar.
html.description.abstractEudraCT nr.: 2010-018761-35.


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