Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study.
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Authors
Triebner, KaiJohannessen, Ane
Puggini, Luca
Benediktsdóttir, Bryndís
Bertelsen, Randi J
Bifulco, Ersilia
Dharmage, Shyamali C
Dratva, Julia
Franklin, Karl A
Gíslason, Thórarinn
Holm, Mathias
Jarvis, Deborah
Leynaert, Bénédicte
Lindberg, Eva
Malinovschi, Andrei
Macsali, Ferenc
Norbäck, Dan
Omenaas, Ernst R
Rodríguez, Francisco J
Saure, Eirunn
Schlünssen, Vivi
Sigsgaard, Torben
Skorge, Trude D
Wieslander, Gunilla
Zemp, Elisabeth
Svanes, Cecilie
Hustad, Steinar
Gómez Real, Francisco
Issue Date
2016-01
Metadata
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Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study. 2016, 137 (1):50-57.e6 J. Allergy Clin. Immunol.Abstract
There is limited and conflicting evidence on the effect of menopause on asthma.We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.
The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.
The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.
New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.
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To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Additional Links
http://dx.doi.org/ 10.1016/j.jaci.2015.08.019Rights
Archived with thanks to The Journal of allergy and clinical immunologyae974a485f413a2113503eed53cd6c53
10.1016/j.jaci.2015.08.019
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