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dc.contributor.authorTriebner, Kai
dc.contributor.authorJohannessen, Ane
dc.contributor.authorPuggini, Luca
dc.contributor.authorBenediktsdóttir, Bryndís
dc.contributor.authorBertelsen, Randi J
dc.contributor.authorBifulco, Ersilia
dc.contributor.authorDharmage, Shyamali C
dc.contributor.authorDratva, Julia
dc.contributor.authorFranklin, Karl A
dc.contributor.authorGíslason, Thórarinn
dc.contributor.authorHolm, Mathias
dc.contributor.authorJarvis, Deborah
dc.contributor.authorLeynaert, Bénédicte
dc.contributor.authorLindberg, Eva
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorMacsali, Ferenc
dc.contributor.authorNorbäck, Dan
dc.contributor.authorOmenaas, Ernst R
dc.contributor.authorRodríguez, Francisco J
dc.contributor.authorSaure, Eirunn
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorSkorge, Trude D
dc.contributor.authorWieslander, Gunilla
dc.contributor.authorZemp, Elisabeth
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorHustad, Steinar
dc.contributor.authorGómez Real, Francisco
dc.date.accessioned2016-04-18T14:47:16Zen
dc.date.available2016-04-18T14:47:16Zen
dc.date.issued2016-01en
dc.date.submitted2016en
dc.identifier.citationMenopause as a predictor of new-onset asthma: A longitudinal Northern European population study. 2016, 137 (1):50-57.e6 J. Allergy Clin. Immunol.en
dc.identifier.issn1097-6825en
dc.identifier.pmid26435006en
dc.identifier.doi10.1016/j.jaci.2015.08.019en
dc.identifier.urihttp://hdl.handle.net/2336/605756en
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractThere is limited and conflicting evidence on the effect of menopause on asthma.
dc.description.abstractWe sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.
dc.description.abstractThe Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.
dc.description.abstractThe odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.
dc.description.abstractNew-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.
dc.description.sponsorshipNorwegian Research Council 228174 214123 Bergen Medical Research Foundation Western Norwegian Regional Health Authorities 911 892 911 631 Norwegian Labour Inspection Norwegian Asthma and Allergy Association Faculty of Health of Aarhus University 240008 Wood Dust Foundation 444508795 Danish Lung Association Swedish Heart-Lung Foundation Vardal Foundation for Health Care Science and Allergy Research Swedish council for working life and social research Bror Hjerpstedt Foundation Swedish Asthma and Allergy Association Icelandic Research Council Estonian Science Foundation 4350en
dc.language.isoenen
dc.publisherMosby-Elsevieren
dc.relation.urlhttp://dx.doi.org/ 10.1016/j.jaci.2015.08.019en
dc.rightsArchived with thanks to The Journal of allergy and clinical immunologyen
dc.subjectAsmaen
dc.subjectTíðahvörfen
dc.subjectPAD12
dc.subject.meshAmenorrheaen
dc.subject.meshAsthmaen
dc.subject.meshEstrogensen
dc.subject.meshLongitudinal Studiesen
dc.subject.meshMenopauseen
dc.subject.meshAgingen
dc.subject.meshSigns and Symptoms, Respiratoryen
dc.subject.meshGonadal Steroid Hormonesen
dc.titleMenopause as a predictor of new-onset asthma: A longitudinal Northern European population study.en
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway [ 2 ] Univ Bergen, Dept Occupat Med, N-5021 Bergen, Norway [ 3 ] Univ Bergen, Core Facil Metab, N-5021 Bergen, Norway [ 4 ] Natl Univ Ireland, Dept Elect Engn, Maynooth, Kildare, Ireland [ 5 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 6 ] Univ Melbourne, Melbourne Sch Populat Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic 3010, Australia [ 7 ] Swiss Trop & Publ Hlth Inst, Dept Publ Hlth & Epidemiol, Basel, Switzerland [ 8 ] Univ Basel, CH-4003 Basel, Switzerland [ 9 ] Umea Univ, Dept Surg & Perioperat Sci, S-90187 Umea, Sweden [ 10 ] Natl Univ Hosp Iceland, Landspitali, Dept Resp Med & Sleep, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 11 ] Gothenburg Univ, Dept Occupat & Environm Med, S-41124 Gothenburg, Sweden [ 12 ] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Resp Epidemiol Occupat Med & Publ Hlth, London SW7 2AZ, England [ 13 ] Inserm UMR1152 Team Epidemiol, Paris, France [ 14 ] Uppsala Univ, Dept Med Sci Lung Med & Allergol, S-75105 Uppsala, Sweden [ 15 ] Uppsala Univ, Clin Physiol, Dept Med Sci, S-75105 Uppsala, Sweden [ 16 ] Haukeland Hosp, Dept Gynecol & Obstet, N-5021 Bergen, Norway [ 17 ] Uppsala Univ, Dept Med Sci Occupat & Environm Med, S-75105 Uppsala, Sweden [ 18 ] Univ Malaga, Dept Appl Math, E-29071 Malaga, Spain [ 19 ] Aarhus Univ, Dept Publ Hlth, DK-8000 Aarhus C, Denmarken
dc.identifier.journalThe Journal of allergy and clinical immunologyen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T15:54:20Z
html.description.abstractThere is limited and conflicting evidence on the effect of menopause on asthma.
html.description.abstractWe sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.
html.description.abstractThe Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.
html.description.abstractThe odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.
html.description.abstractNew-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.


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