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dc.contributor.authorDratva, Julia
dc.contributor.authorZemp, Elisabeth
dc.contributor.authorDharmage, Shyamali C
dc.contributor.authorAccordini, Simone
dc.contributor.authorBurdet, Luc
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorJanson, Christer
dc.contributor.authorJarvis, Deborah
dc.contributor.authorde Marco, Roberto
dc.contributor.authorNorbäck, Dan
dc.contributor.authorPons, Marco
dc.contributor.authorReal, Francisco Gómez
dc.contributor.authorSunyer, Jordi
dc.contributor.authorVillani, Simona
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorSvanes, Cecilie
dc.date.accessioned2016-04-20T12:52:20Zen
dc.date.available2016-04-20T12:52:20Zen
dc.date.issued2016en
dc.date.submitted2016en
dc.identifier.citationPLoS ONE 2016, 11 (1):e0145127en
dc.identifier.issn1932-6203en
dc.identifier.pmid26811913en
dc.identifier.doi10.1371/journal.pone.0145127en
dc.identifier.urihttp://hdl.handle.net/2336/606069en
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractEarly life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.
dc.description.abstractSpirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression.
dc.description.abstractEarly life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking. The effects were independent of asthma at any age.
dc.description.abstractEarly life factors predicted lung function decline decades later, suggesting that some mechanisms related lung ageing may be established early in life. Early life programming of susceptibility to adult insults could be a possible pathway that should be explored further.
dc.description.sponsorshipSwiss National Science Foundation PMPDP3_129021/1 PMPDP3_141671/1 Lung league Beider Basel, Lung league Graubunden Stiftung ehemals Bundner Heilstatten COST action BM1201 SAPALDIA ECRHSen
dc.language.isoenen
dc.publisherPublic Library Scienceen
dc.relation.urlhttp://dx.doi.org/ 10.1371/journal.pone.0145127en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728209/en
dc.rightsArchived with thanks to PloS oneen
dc.subjectLungnasjúkdómaren
dc.subjectUmhverfisáhrifen
dc.subjectReykingaren
dc.subjectAsmaen
dc.subjectBörnen
dc.subjectForeldraren
dc.subjectPAD12
dc.subject.meshLungen
dc.subject.meshLife Styleen
dc.subject.meshPulmonary Disease, Chronic Obstructiveen
dc.subject.meshSmoking/adverse effectsen
dc.subject.meshAsthmaen
dc.subject.meshAge of Onseten
dc.titleEarly Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years.en
dc.typeArticleen
dc.contributor.department[ 1 ] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland [ 2 ] Univ Basel, Basel, Switzerland [ 3 ] Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Allergy & Lung Hlth Unit, Melbourne, Vic 3010, Australia [ 4 ] Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37100 Verona, Italy [ 5 ] Hop Intercantonal Broye, Payerne, Switzerland [ 6 ] Landspitali Univ, Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland [ 7 ] Helmholtz Ctr Munich, Natl Res Ctr Environm Hlth, Munich, Germany [ 8 ] Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany [ 9 ] German Ctr Lung Res DZ, Munich, Germany [ 10 ] Uppsala Univ, Dept Med Sci Resp Med & Allergol, Uppsala, Sweden [ 11 ] Univ London Imperial Coll Sci Technol & Med, Dept Publ Hlth Sci, London, England [ 12 ] Uppsala Univ, Dept Med Sci Occupat Environm Med, Uppsala, Sweden [ 13 ] Reg Hosp Lugano, Div Pulm Med, Lugano, Switzerland [ 14 ] Univ Bergen, Dept Clin Sci, Bergen, Norway [ 15 ] Haukeland Hosp, Dept Obstet & Gynaecol, N-5021 Bergen, Norway [ 16 ] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain [ 17 ] Univ Pavia, Fac Med, Dept Publ Hlth Neurosci Expt & Legal Med, Via Palestro 3, I-27100 Pavia, Italy [ 18 ] Univ Bergen, Ctr Int Hlth, Bergen Resp Res Grp, Bergen, Norway [ 19 ] Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norwayen
dc.identifier.journalPloS oneen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T15:55:10Z
html.description.abstractEarly life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.
html.description.abstractSpirometry data from two time points (follow-up time 9-11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28-73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression.
html.description.abstractEarly life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking. The effects were independent of asthma at any age.
html.description.abstractEarly life factors predicted lung function decline decades later, suggesting that some mechanisms related lung ageing may be established early in life. Early life programming of susceptibility to adult insults could be a possible pathway that should be explored further.


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